Stem cells for therapy in TBI

Journal of the Royal Army Medical Corps
Aminul Islam AhmedM Ross Bullock

Abstract

While the pace of traumatic brain injury (TBI) research has accelerated, the treatment options remain limited. Clinical trials are yet to yield successful treatment options, leading to innovative strategies to overcome the severe debilitating consequences of TBI. Stem cells may act as a potential treatment option. They have two key characteristics, the ability of self-renewal and the ability to give rise to daughter cells, which in the case of neural stem cells (NSCs) includes neurons, astrocytes and oligodendrocytes. They respond to the injury environment providing trophic support and have been shown to differentiate and integrate into the host brain. In this review, we introduce the notion of an NSC and describe the two neurogenic niches in the mammalian brain. The literature supporting the activation of an NSC in rodent models of TBI, both in vivo and in vitro, is detailed. This endogenous activation of NSCs may be augmented by exogenous transplantation of NSCs. Delivery of NSCs to assist the host nervous system has become an attractive option, with either fetal or adult NSC. This has resulted in cognitive and functional improvement in rodents, and current animal studies are using human NSCs. While no NSC clinical trials are...Continue Reading

References

Aug 1, 1991·Trends in Neurosciences·E Cattaneo, R McKay
Jun 1, 1965·The Journal of Comparative Neurology·J Altman, G D Das
Jan 1, 1995·Annual Review of Neuroscience·F H GageL J Fisher
Feb 1, 1996·Current Opinion in Neurobiology·S Temple, X Qian
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·B D YandavaE Y Snyder
Feb 15, 2001·Journal of Neuroscience Research·P K DashA N Moore
Jun 26, 2001·Experimental Neurology·Y ArsenijevicP Aebischer
Dec 18, 2001·Journal of Neuroscience Research·S G KernieL F Parada
Aug 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kunlin JinDavid A Greenberg
Sep 3, 2002·Journal of Neuroscience Research·Hideyuki Okano
Apr 30, 2004·Journal of Neurotrauma·Haitham SalmanSteven G Kernie
Aug 12, 2004·Neuroreport·Faiez Al NimerTiit Mathiesen
Jul 30, 2005·Brain Research·Shilpa RamaswamyDorothy A Kozlowski
May 19, 2006·Acta neurochirurgica·R M RichardsonH L Fillmore
Jul 10, 2007·Progress in Brain Research·Helen M Bramlett, W Dalton Dietrich
Feb 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Annalisa BuffoMagdalena Götz
Jun 27, 2009·Annual Review of Neuroscience·Arnold Kriegstein, Arturo Alvarez-Buylla
Jan 7, 2010·The Journal of Clinical Investigation·Olle Lindvall, Zaal Kokaia
Feb 4, 2010·Current Opinion in Neurology·Irina Kharatishvili, Asla Pitkänen
Feb 18, 2010·Journal of Neurotrauma·Dong SunRaymond J Colello
Apr 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cory A BlaissSteven G Kernie
Jan 1, 1990·Restorative Neurology and Neuroscience·S Finger
Jun 24, 2011·Restorative Neurology and Neuroscience·Deborah A ShearGary L Dunbar
Jun 29, 2011·Annals of Neurology·Anil F RamlackhansinghDavid J Sharp

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Citations

Dec 19, 2020·Translational Neuroscience·Zhike ZhouQinghua Li

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