Stem cells in genetically-engineered mouse models of prostate cancer

Endocrine-related Cancer
Maho Shibata, Michael M Shen

Abstract

The cancer stem cell model proposes that tumors have a hierarchical organization in which tumorigenic cells give rise to non-tumorigenic cells, with only a subset of stem-like cells able to propagate the tumor. In the case of prostate cancer, recent analyses of genetically engineered mouse (GEM) models have provided evidence supporting the existence of cancer stem cells in vivo. These studies suggest that cancer stem cells capable of tumor propagation exist at various stages of tumor progression from prostatic intraepithelial neoplasia (PIN) to advanced metastatic and castration-resistant disease. However, studies of stem cells in prostate cancer have been limited by available approaches for evaluating their functional properties in cell culture and transplantation assays. Given the role of the tumor microenvironment and the putative cancer stem cell niche, future studies using GEM models to analyze cancer stem cells in their native tissue microenvironment are likely to be highly informative.

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Citations

Feb 28, 2016·Biochimica Et Biophysica Acta·John R Packer, Norman J Maitland
Oct 22, 2015·Endocrine-related Cancer·Dean G Tang
Apr 18, 2018·Cold Spring Harbor Perspectives in Medicine·Juan M Arriaga, Cory Abate-Shen
Apr 4, 2017·The Journal of Clinical Investigation·Anna C Groner, Myles Brown
Oct 7, 2018·Cold Spring Harbor Perspectives in Medicine·Jia J Li, Michael M Shen

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