Stem cells in nephrology: present status and future

Archivum Immunologiae Et Therapiae Experimentalis
Ewa Watorek, Marian Klinger

Abstract

Stem cell biology is currently developing rapidly because of the potential therapeutic utility of stem cells. The ability to acquire any desired phenotype raises hope for regenerative therapies. Manipulation of these cells is a potentially valuable tool; however, the mechanisms of stem cell differentiation and plasticity are currently beyond our control. In the field of nephrology, the presence of adult kidney stem cells has been debated. Renal adult stem cells may be descendants of some early kidney progenitors, or may be derived from bone marrow. Evidence of a hematopoietic stem-cell contribution to renal repair encourages the possibility of bone marrow or stem cell transplantation as a means of treating autoimmune glomerulopathies. The transplantation of fetal kidney tissue containing renal progenitors, which then develop into functional nephrons, is a step towards renal regeneration. According to recent reports, the development of functional nephrons from human mesenchymal stem cells in rodent whole-embryo culture is possible. Establishing in vitro self organs from autologous stem cells would be a promising therapeutic solution in light of the shortage of allogenic organs and the unresolved problem of chronic allograft reje...Continue Reading

Citations

Mar 8, 2008·Clinical Neurology and Neurosurgery·Shimon SlavinDimitrios Karussis
Mar 28, 2008·Journal of Cellular and Molecular Medicine·Anna Aihua LiPatricia L Chang
Aug 24, 2010·Journal of Neuroimmunology·Bassem YamoutAli Bazarbachi
Apr 25, 2012·Cell Transplantation·Young Youl HyunDae Ryong Cha
Mar 27, 2007·Clinical and Experimental Nephrology·Masamichi EguchiTakayuki Asahara

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