PMID: 6407542Jul 1, 1983Paper

Stem cells in normal and leukemic hemopoiesis (Henry Stratton Lecture, 1982).

Blood
E A McCulloch

Abstract

This paper deals with three themes: (1) the nature of differentiation in normal and leukemic processes, (2) stochastic and deterministic control mechanisms that affect differentiation, and (3) the nature of the events that separate self-renewing stem cells from their committed descendants. These all impinge on both myelopoietic and lymphopoietic leukemias. The view is advanced that differentiation continues in these diseases, but new programs are assembled abnormally but with normal components.

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.