Stem cells in the adult rat spinal cord: plasticity after injury and treadmill training exercise

Journal of Neurochemistry
Ariane ForetRachelle Franzen

Abstract

Ependymal cells located around the central canal of the adult spinal cord are considered as a source of neural stem cells (NSCs) and represent an interesting pool of endogenous stem cells for repair strategies. Physical exercise is known to increase ependymal cell proliferation, while improving functional recovery. In this work, we further characterized those endogenous NSCs within the normal and injured adult rat spinal cord and investigated the effects of treadmill training using immunohistochemical and behavioral studies. In uninjured untrained rats, Sox-2, a NSC marker, was detected in all ependymal cells of the central canal, and also scattered throughout the parenchyma of the spinal cord. Within the lesion, Sox-2 expression increased transiently, while the number of nestin-positive ependymal cells increased with a concomitant enhancement of proliferation, as indicated by the mitotic markers Ki67 and bromo-deoxyuridine. Exercise, which improved functional recovery and autonomous micturition, maintained nestin expression in both injured and uninjured spinal cords, with a positive correlation between locomotor recovery and the number of nestin-positive cells.

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Citations

Jul 21, 2011·Journal of Neurotrauma·Olivier AlluinSerge Rossignol
Feb 26, 2011·Journal of Tissue Engineering·Jung Keun Hyun, Hae-Won Kim
Oct 1, 2015·Journal of Neurotrauma·Ana Beatriz W MarcosClaudia Pinto Figueiredo
Mar 26, 2016·Frontiers in Cellular Neuroscience·Yilin MaoCatherine A Gorrie
Mar 26, 2015·Neuroscience Letters·Margarita V GlazovaAlexander K Murashov
Jul 15, 2015·Journal of Materials Science. Materials in Medicine·Laura Alvarez-MejiaHermelinda Salgado-Ceballos
Feb 22, 2011·Experimental Neurology·Crystal A RuffMichael G Fehlings
Jan 23, 2016·Veterinary Pathology·S A Moore
Mar 18, 2017·Expert Opinion on Biological Therapy·Anna BadnerMichael G Fehlings
May 16, 2014·Scientific Reports·Kenji SuehiroYoshinori Takei
Dec 15, 2017·Neural Regeneration Research·Tara NguyenCatherine Anne Gorrie
Jun 9, 2018·International Journal of Molecular Sciences·Dana M OtzelJoshua F Yarrow
May 31, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Aline M ThomasLonnie D Shea
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Jun 14, 2019·Stem Cells International·Sumei Liu, Zhiguo Chen
Mar 2, 2019·Seminars in Cell & Developmental Biology·Yang D Teng
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