Stem cells in the embryonic kidney

Kidney International
Ryuichi Nishinakamura

Abstract

The mammalian kidney, the metanephros, is formed by a reciprocally inductive interaction between two precursor tissues, the metanephric mesenchyme and the ureteric bud. The ureteric bud induces the metanephric mesenchyme to differentiate into the epithelia of glomeruli and renal tubules. Multipotent renal progenitors that form colonies upon Wnt4 stimulation and strongly express Sall1 exist in the metanephric mesenchyme; these cells can partially reconstitute a three-dimensional structure in an organ culture setting. Six2 maintains this mesenchymal progenitor population by opposing Wnt4-mediated epithelialization. Upon epithelial tube formation, Notch2 is required for the differentiation of proximal nephron structures (podocyte and proximal tubules). In addition, the induction methods of the intermediate mesoderm, the precursor of the metanephric mesenchyme, begin to be elucidated. If derivation of metanephric mesenchyme becomes possible, we will be closer to the generation and manipulation of multiple cell lineages in the kidney.

References

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Citations

Aug 9, 2011·Histochemistry and Cell Biology·Will W MinuthAnne Glashauser
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yukako UchiyamaRyuichi Nishinakamura
Jan 8, 2010·Journal of Biochemistry·Qing JiangRyuichi Nishinakamura
Feb 12, 2009·Development, Growth & Differentiation·Naoki WatanabeYuko Wakamatsu
Jul 8, 2009·Pediatric Research·Alyssa C LeapleyAlice F Tarantal
Mar 20, 2010·Journal of the American Society of Nephrology : JASN·Sayoko FujimuraRyuichi Nishinakamura
Oct 14, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Daniela FanniGavino Faa
Feb 13, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ryuichi NishinakamuraAtsuhiro Taguchi
Jan 29, 2011·Kidney International·Ramon G B BonegioDavid J Salant
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Feb 18, 2012·Journal of Biomedical Materials Research. Part a·Will W Minuth, Lucia Denk
Feb 4, 2010·Genesis : the Journal of Genetics and Development·Shuji InoueRyuichi Nishinakamura
Nov 26, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Brittany WongScott Lozanoff
May 27, 2011·Organogenesis·Scott Reule, Sandeep Gupta
Jul 3, 2013·International Journal of Molecular Sciences·Will W Minuth, Lucia Denk
Apr 20, 2014·Journal of the American Society of Nephrology : JASN·Shoichiro KandaRyuichi Nishinakamura
Oct 16, 2009·American Journal of Physiology. Renal Physiology·Sandeep GuptaMark Rosenberg
Jan 24, 2020·Expert Opinion on Biological Therapy·Anna Julie PeiredElena Lazzeri
Jun 18, 2017·Frontiers in Bioengineering and Biotechnology·Afrânio Côgo DestefaniBreno Valentim Nogueira
Jul 5, 2017·Scientific Reports·Yusuke KakuRyuichi Nishinakamura
Jun 13, 2015·Current Opinion in Nephrology and Hypertension·Francesco CellesiMaria Pia Rastaldi
Mar 26, 2021·Frontiers in Physiology·Carolyn Mary Ecelbarger

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