Stem Cells in the Limbal Stroma

The Ocular Surface
James L FunderburghYiqin Du

Abstract

The corneal stroma contains a population of mesenchymal cells subjacent to the limbal basement membrane with characteristics of adult stem cells. These 'niche cells' support limbal epithelial stem cell viability. In culture by themselves, the niche cells display a phenotype typical of mesenchymal stem cells. These stromal stem cells exhibit a potential to differentiate to multiple cell types, including keratocytes, thus providing an abundant source of these rare cells for experimental and bioengineering applications. Stromal stem cells have also shown the ability to remodel pathological stromal tissue, suppressing inflammation and restoring transparency. Because stromal stem cells can be obtained by biopsy, they offer a potential for autologous stem cell treatment for stromal opacities. This review provides an overview of the status of work on this interesting cell population.

References

Dec 1, 1977·Developmental Biology·C Cintron, C L Kublin
Apr 27, 1999·Progress in Retinal and Eye Research·M E Fini
May 2, 2000·The Journal of Biological Chemistry·C J LongJ L Funderburgh
Jan 3, 2001·Experimental Eye Research·J D ZieskeA E Hutcheon
Aug 23, 2003·The Journal of Biological Chemistry·James L FunderburghMartha L Funderburgh
Oct 30, 2004·Current Eye Research·Yanira OsorioHomayon Ghiasi
Nov 24, 2004·The International Journal of Developmental Biology·James D Zieske
Apr 27, 2005·Investigative Ophthalmology & Visual Science·Satoru YoshidaKazuo Tsubota
May 20, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martha L FunderburghJames L Funderburgh
Jul 29, 2005·Pathology, Research and Practice·Nóra SzentmáryIldikó Süveges
Jul 30, 2005·Stem Cells·Yiqin DuJames L Funderburgh
Oct 27, 2005·Investigative Ophthalmology & Visual Science·Motonobu UenoLeonard D Shultz
Sep 27, 2006·Cornea·Shiro AmanoSeiichi Yokoo
Oct 17, 2006·Medicinski pregled·Slobodanka Latinović
Aug 29, 2007·Investigative Ophthalmology & Visual Science·James V JesterW Matthew Petroll
Oct 27, 2007·Investigative Ophthalmology & Visual Science·Yiqin DuJames L Funderburgh
Jul 16, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R RenV Trinkaus-Randall
Mar 12, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ching-Kuang ChuangYu-Chen Hu
Jun 23, 2009·Stem Cells·Yiqin DuJames L Funderburgh
Oct 9, 2009·Journal of Tissue Engineering and Regenerative Medicine·Xiaomin ZhangShaozhen Zhao
Jul 6, 2010·Experimental Eye Research·John R Hassell, David E Birk
Jul 31, 2010·Nature Protocols·Indumathi MariappanGeeta K Vemuganti
Sep 4, 2010·Stem Cell Research·Maria NotaraJulie T Daniels
Oct 12, 2010·Endocrine, Metabolic & Immune Disorders Drug Targets·Osamu YamanakaWinston W-Y Kao
Oct 26, 2010·Experimental Eye Research·S Louise AinscoughDamien G Harkin
Dec 24, 2010·Tissue Engineering. Part C, Methods·Szu-Yu ChenScheffer C G Tseng
Feb 8, 2011·Cell Stem Cell·Anna GolebiewskaSimone P Niclou
Sep 6, 2011·The British Journal of Ophthalmology·Virender S SangwanDorairajan Balasubramanian
Dec 15, 2011·Investigative Ophthalmology & Visual Science·Hua-Tao XieScheffer C G Tseng
Apr 3, 2012·Investigative Ophthalmology & Visual Science·Craig BooteKeith M Meek
Jun 16, 2012·Immunology Letters·Sara M Rankin
Jul 28, 2012·Investigative Ophthalmology & Visual Science·Gui-Gang LiScheffer C G Tseng
May 7, 2013·Current Molecular Medicine·J Stagg, J Galipeau
Jun 27, 2013·Stem Cell Research & Therapy·Khurram HashmaniHarminder Singh Dua
Jul 3, 2013·Journal of Cell Science·Matilda F ChanZena Werb

❮ Previous
Next ❯

Citations

Jul 12, 2016·Journal of Refractive Surgery·Miguel A Teus, Laura de Benito-Llopis
Mar 4, 2017·Clinical & Experimental Ophthalmology·Samuel McLenachanFred K Chen
Jan 26, 2017·Journal of Cellular Biochemistry·Liliana I Sous NaasaniMárcia R Wink
Apr 12, 2017·Current Opinion in Ophthalmology·Ghasem YazdanpanahAli R Djalilian
Jun 13, 2017·International Journal of Molecular Sciences·Anne BukowieckiSabine A Eming
Apr 15, 2018·Stem Cells Translational Medicine·Golnar ShojaatiJames L Funderburgh
Apr 22, 2018·Journal of Cellular and Molecular Medicine·Ping GuoYingting Zhu
Jul 11, 2019·Stem Cells Translational Medicine·Golnar ShojaatiJames L Funderburgh
Jan 29, 2020·Biology Open·Satu KujawskiElisabeth Knust
May 8, 2020·Stem Cells Translational Medicine·Djida GhoubayVincent M Borderie
Nov 7, 2017·Wiley Interdisciplinary Reviews. Developmental Biology·Gabriel GonzalezNatasha Y Frank
Jul 10, 2019·Current Eye Research·Sachin ShuklaSayan Basu
Jul 28, 2017·Stem Cells·Mehrnoosh SaghizadehAlexander V Ljubimov
Apr 13, 2017·Neural Regeneration Research·Israel AharonyNitza Goldenberg-Cohen
Jul 28, 2018·Journal of Ophthalmology·Ying DongRobert M Lavker
Jul 17, 2019·Investigative Ophthalmology & Visual Science·Aurelie Dos SantosSophie X Deng
Sep 20, 2019·Journal of Clinical Medicine·Federico BernabeiPiera Versura
Jun 20, 2019·International Journal of Molecular Sciences·Hassan MansoorGary Hin-Fai Yam
Dec 16, 2020·Investigative Ophthalmology & Visual Science·Yu-Ting XiaoXin-Yue Zhao
Jan 30, 2021·Frontiers in Cell and Developmental Biology·Sean AshworthAndrew J Quantock
Dec 22, 2020·Experimental Eye Research·Thomas L A VolatierChe J Connon
Nov 1, 2020·The Ocular Surface·Sabeeh Kamil, Rajiv R Mohan
Feb 3, 2021·International Immunopharmacology·Zewen WuLiyun Zhang
May 23, 2020·Experimental Eye Research·Gary H F YamVishal Jhanji
Jul 15, 2020·Experimental Eye Research·Edgar M Espana, David E Birk
Jun 18, 2021·World Journal of Stem Cells·Giovanni MiottiMarco Zeppieri
Aug 24, 2021·The Ocular Surface·Naresh PolisettiUrsula Schlötzer-Schrehardt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.