Stem cells in the lung parenchyma and prospects for lung injury therapy

European Journal of Clinical Investigation
C C YenC M Chen

Abstract

Until recently, it was thought that only embryonic stem cells were pluripotent and that adult stem cells were restricted in their differentiative and regenerative potential to become the tissues in which they reside. However, the discovery that adult stem cells in one tissue can contribute to the formation of other tissues, especially after injury or cell damage, implies that stem cells have developmental plasticity. For example, haematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) from bone marrow can be used to regenerate diverse tissues at distant sites, including the lung. This article reviews the character of stem cells in the lung parenchyma and focuses on the potential uses of adult stem cells in research of lung injury and lung disease therapies.

References

Feb 1, 1975·Experimental and Molecular Pathology·M J EvansG Freeman
Feb 1, 1992·The American Journal of Physiology·F StahlM Wiederholt
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G J Spangrude, G R Johnson
Oct 1, 1995·The Journal of Clinical Investigation·R J PanosL J Smith
May 1, 1995·American Journal of Respiratory Cell and Molecular Biology·W V CardosoJ S Brody
May 1, 1995·American Journal of Respiratory Cell and Molecular Biology·S I DantoE D Crandall
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·R F PereiraD J Prockop
Feb 11, 1994·The American Journal of Physiology·H LumA B Malik
Oct 1, 1996·American Journal of Respiratory Cell and Molecular Biology·T YanoR J Mason
May 1, 1997·American Journal of Respiratory and Critical Care Medicine·B P GueryS Nelson
Jun 1, 1997·Nature Medicine·G D Massaro, D Massaro
Feb 12, 1998·The American Journal of Physiology·D C Devor, R A Frizzell
May 2, 1998·American Journal of Respiratory Cell and Molecular Biology·Z BorokE D Crandall
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·Z HouG S Stein
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·K A JacksonM A Goodell
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N D TheiseD S Krause
Jan 5, 2000·Nature·J B Gurdon, A Colman
Jan 27, 2000·Cell·E Fuchs, J A Segre
Feb 26, 2000·Science·F M Watt, B L Hogan
Mar 10, 2000·Science·T ChengD T Scadden
Apr 25, 2000·Annual Review of Medicine·R ParkmanD Kohn
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Jun 2, 2000·Science·D L ClarkeJ Frisén
Jun 3, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·S FlecknoeS B Hooper
Jun 3, 2000·Nature Medicine·J E Dick
Aug 5, 2000·Nature·M R AlisonN A Wright
Feb 13, 2001·Cell·S J OdelbergM T Keating
Feb 22, 2001·Annual Review of Physiology·W V Cardoso
Feb 24, 2001·Yonsei Medical Journal·H Suh
Mar 7, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Sell
Apr 5, 2001·Nature·D OrlicP Anversa
Jun 21, 2001·American Journal of Respiratory Cell and Molecular Biology·J F Engelhardt
Jun 21, 2001·American Journal of Respiratory Cell and Molecular Biology·D W BorthwickS H Randell
Jun 28, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B MurdochM Bhatia
Jul 6, 2001·Cell·H M BlauJ M Weimann

❮ Previous
Next ❯

Citations

Mar 15, 2008·Reproductive Biomedicine Online·Keelin O'DonoghueNicholas M Fisk
Jul 12, 2008·Human Reproduction·Margarida Avo SantosNicholas M Fisk
Jul 16, 2008·Proceedings of the American Thoracic Society·Daniel J WeissDarwin J Prockop
Mar 3, 2009·Seminars in Radiation Oncology·Rob P CoppesIsabelle M A Lombaert
May 22, 2007·Médecine et maladies infectieuses·T SeguinJ-P Mira
Aug 28, 2010·Oral Diseases·R P Coppes, M A Stokman
Jan 7, 2009·Therapeutic Advances in Respiratory Disease·Dario SiniscalcoBruno D'Agostino
Jan 1, 2013·Réanimation : Journal De La Société De Réanimation De Langue Française·S GaudryJ-D Ricard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.