Stem cells supporting other stem cells

Frontiers in Genetics
Judith L Leatherman

Abstract

Adult stem cell therapies are increasingly prevalent for the treatment of damaged or diseased tissues, but most of the improvements observed to date are attributed to the ability of stem cells to produce paracrine factors that have a trophic effect on existing tissue cells, improving their functional capacity. It is now clear that this ability to produce trophic factors is a normal and necessary function for some stem cell populations. In vivo adult stem cells are thought to self-renew due to local signals from the microenvironment where they live, the niche. Several niches have now been identified which harbor multiple stem cell populations. In three of these niches - the Drosophila testis, the bulge of the mammalian hair follicle, and the mammalian bone marrow - one type of stem cell has been found to produce factors that contribute to the maintenance of a second stem cell population in the shared niche. In this review, I will examine the architecture of these three niches and discuss the molecular signals involved. Together, these examples establish a new paradigm for stem cell behavior, that stem cells can promote the maintenance of other stem cells.

Citations

Jul 26, 2014·International Journal of Molecular Sciences·Deying ZhangGuanghui Wei
Jun 18, 2015·Frontiers in Cellular Neuroscience·Fabio CavaliereNadia D'Ambrosi
Oct 10, 2015·The British Journal of Dermatology·R PausA Izeta
Jun 6, 2018·Journal of Cellular Physiology·Javad Amini MahabadiHossein Nikzad
Mar 20, 2016·BMC Developmental Biology·Amanda J Monahan, Michelle Starz-Gaiano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
Hilda Amalia Pasolli
Cellular and Molecular Life Sciences : CMLS
Jill Goldstein, Valerie Horsley
Annual Review of Cell and Developmental Biology
Linheng Li, Ting Xie
Frontiers in Bioscience (Landmark Edition)
Dongsu ParkD T Scadden
© 2021 Meta ULC. All rights reserved