Stemness of the organ of Corti relates to the epigenetic status of Sox2 enhancers.

PloS One
Jörg WaldhausH Löwenheim

Abstract

In the adult mammalian auditory epithelium, the organ of Corti, loss of sensory hair cells results in permanent hearing loss. The underlying cause for the lack of regenerative response is the depletion of otic progenitors in the cell pool of the sensory epithelium. Here, we show that an increase in the sequence-specific methylation of the otic Sox2 enhancers NOP1 and NOP2 is correlated with a reduced self-renewal potential in vivo and in vitro; additionally, the degree of methylation of NOP1 and NOP2 is correlated with the dedifferentiation potential of postmitotic supporting cells into otic stem cells. Thus, the stemness the organ of Corti is related to the epigenetic status of the otic Sox2 enhancers. These observations validate the continued exploration of treatment strategies for dedifferentiating or reprogramming of differentiated supporting cells into progenitors to regenerate the damaged organ of Corti.

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Citations

Jun 19, 2014·BioResearch Open Access·Marc DiensthuberTimo Stöver
Oct 18, 2013·Neural Development·Heiko LocherSusana M Chuva de Sousa Lopes
Jan 21, 2016·Scientific Reports·Dean P CampbellAngelika Doetzlhofer
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Mar 1, 2013·Developmental Neurobiology·Robyn JacksonMichael G Jonz
Oct 24, 2014·Molecular Neurobiology·Tiantian Cai, Andrew K Groves
Aug 6, 2013·Hearing Research·Wanda S LaymanJian Zuo
Dec 26, 2018·Expert Opinion on Biological Therapy·Patrick J AtkinsonAlan G Cheng
Jan 27, 2019·Hearing Research·Bradley J Walters, Brandon C Cox
Apr 9, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bruce B Riley
Apr 30, 2015·Development·Patrick J AtkinsonAlan G Cheng

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Datasets Mentioned

BETA
AB092842.1
AL606746.17
AC117415.7

Methods Mentioned

BETA
fluorescence-activated cell sorting
transgenic
Reverse Transcription Polymerase Chain
PCR

Software Mentioned

Genomatix DiAlign professional
YEASTRACT
EpiTyper
Genomatix
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