Stenotrophomonas maltophilia biofilm reduction by Bdellovibrio exovorus

Environmental Microbiology Reports
Ryan M ChanyiJoanna S Brooke

Abstract

Stenotrophomonas maltophilia, a bacterium ubiquitous in the environment, is also an opportunistic, multidrug-resistant human pathogen that colonizes tissues and medical devices via biofilm formation. We investigated the ability of an isolate from sewage of the bacterial predator Bdellovibrio exovorus to disrupt preformed biofilms of 18 strains of S. maltophilia isolated from patients, hospital sink drains and water fountain drains. B. exovorus FFRS-5 preyed on all S. maltophilia strains in liquid co-cultures and was able to significantly disrupt the biofilms of 15 of the S. maltophilia strains tested, decreasing as much as 76.7% of the biofilm mass. The addition of ciprofloxacin and kanamycin in general reduced S. maltophilia biofilms but less than that of B. exovorus alone. Furthermore, when antibiotics and B. exovorus were used together, B. exovorus was still effective in the presence of ciprofloxacin whereas the addition of kanamycin reduced the effectiveness of B. exovorus. Overall, B. exovorus was able to decrease the mass of preformed biofilms of S. maltophilia in the presence of clinically relevant antibiotics demonstrating that the predator may prove to be a beneficial tool to reduce S. maltophilia environmental or clin...Continue Reading

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Citations

Sep 16, 2016·Scientific Reports·Ajay K MonnappaRobert J Mitchell
Feb 9, 2017·Canadian Journal of Microbiology·Damian McNeelySusan F Koval
Oct 30, 2019·Expert Review of Anti-infective Therapy·Samantha Flores-TreviñoElvira Garza-González
Nov 14, 2018·Infectious Diseases·Angelina Trifonova, Tanya Strateva
Jun 27, 2017·NPJ Biofilms and Microbiomes·Tomohiro InabaHiroshi Habe
May 1, 2020·Frontiers in Microbiology·Eleni BratanisEwa Bukowska-Faniband
May 14, 2017·Scientific Reports·Kenneth ShatzkesNancy D Connell
Oct 10, 2020·Computational and Structural Biotechnology Journal·Juana PérezJosé Muñoz-Dorado

Related Concepts

Interference, Bacterial
Bacteriocidal Agents
Bdellovibrio
Ciprinol
Environmental Microbiology
Kantrex
Environmental Sludge
Gram-Negative Bacterial Infections
Microbial Biofilms
Stenotrophomonas maltophilia

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