Step-down-type passive avoidance- and escape-learning method. Suitability for experimental amnesia models

Journal of Pharmacological Methods
T KameyamaT Kozawa

Abstract

A method for evaluating passive avoidance- and escape-learning responses simultaneously has been developed for the study of learning and memory in mice. Prolongation of the step-down latency and shortening of the escape latency in the retention test depended on the strength of the voltage of the electric shocks delivered during the training test. Therefore, the step-down latency and escape latency may be good parameters of learning and memory performance. By cycloheximide treatment immediately after training, the step-down latency and escape latency were shortened and prolonged, respectively, in a dose-related manner, and the relationship between the step-down latency and escape latency was significant. Treatment with cycloheximide within 30 min after training caused significant amnesia, but not after more than 60 min. Furthermore, amnesic action of cycloheximide developed 24 hr after the treatment, but not within 4 hr. On the other hand, the step-down latency and/or the escape latency in the training test were changed by pretreatment with diethyldithiocarbamate and scopolamine. Therefore, the amnesic action of these drugs administered before the training should be investigated in detail. The present method, simultaneously esti...Continue Reading

References

Dec 1, 1976·Hormones and Behavior·P E Gold, R van Buskirk
Dec 1, 1977·Journal of Comparative and Physiological Psychology·E E Quinton, A S Bloom
Dec 15, 1978·European Journal of Pharmacology·G L Kovács, D de Wied
Jan 1, 1975·Journal of Comparative and Physiological Psychology·S Nakajima
Jul 1, 1974·Journal of Comparative and Physiological Psychology·D A Feigley
Sep 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·B W AgranoffJ J Brink
Aug 1, 1967·Journal of Comparative and Physiological Psychology·R KoppM E Jarvik
Mar 1, 1984·Journal of Pharmacobio-dynamics·T Kameyama, M Nagasaka
Apr 1, 1983·Behavioral Neuroscience·A P Leccese, E E Quinton
Jan 1, 1982·Neurobiology of Aging·R B MessingV J Nickolson
Mar 1, 1982·Pharmacology, Biochemistry, and Behavior·M E Judge, D Quartermain
Oct 1, 1982·Behavioral and Neural Biology·S J Sara, B Deweer
Mar 1, 1981·Journal of Medicinal Chemistry·D E ButlerJ G Marriott
Aug 1, 1981·Pharmacology, Biochemistry, and Behavior·O L Wolthuis
Apr 1, 1980·Experimental Aging Research·L W MeansC E Cliett
Oct 1, 1961·Journal of Comparative and Physiological Psychology·M C MADSEN, J L McGAUGH

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Citations

Jan 1, 1992·Journal of Neural Transmission. General Section·T ShiotaniT Nabeshima
Jul 9, 2010·Biological Trace Element Research·Haiquan ZhaoFashui Hong
Oct 12, 2012·Biological Trace Element Research·Bing LiFashui Hong
Nov 8, 2012·Biological Trace Element Research·Cristiani Folharini BortolattoCristina Wayne Nogueira
Mar 20, 1990·European Journal of Pharmacology·T NabeshimaT Kameyama
Mar 30, 1993·European Journal of Pharmacology·K Shimosato, T Saito
Sep 1, 1986·Pharmacology, Biochemistry, and Behavior·T KameyamaT Kozawa
Nov 1, 1988·Pharmacology, Biochemistry, and Behavior·H L KomiskeyK L Mundinger
Oct 1, 1988·Pharmacology, Biochemistry, and Behavior·T NabeshimaT Kameyama
Oct 1, 1992·Pharmacology, Biochemistry, and Behavior·H SasakiK Sekizawa
Mar 23, 2004·European Journal of Pharmacology·Mohammad R ZarrindastBijan Djahanguiri
Feb 27, 2004·Physiology & Behavior·Tomoaki SatoTakashige Nishikawa
Jan 4, 1998·European Journal of Pharmacology·M UkaiT Kameyama
Dec 28, 2006·Pharmacology·Nazanin MalekmohamadiMohammad-Reza Zarrindast
Nov 16, 2012·BMC Complementary and Alternative Medicine·Rahmat Ali Khan
Jan 18, 2011·Behavioural Brain Research·Magdalini A PapandreouMarigoula Margarity
Mar 2, 2010·European Journal of Pharmacology·Mohammad NasehiMohammad Reza Zarrindast
Mar 7, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Rosane GomezMarina Godinho Wieczorek
May 18, 2012·Behavioral and Brain Functions : BBF·Rahmat Ali KhanSumaira Sahreen
Dec 21, 2005·Physiology & Behavior·Mohammad Reza ZarrindastSaeid Hosein Yahyavi
Oct 31, 2012·Pharmacology, Biochemistry, and Behavior·Ipek Komsuoglu CelikyurtFeyza Aricioglu
Jul 17, 2012·Pharmacology, Biochemistry, and Behavior·Tijen UtkanFeyza Aricioglu
Sep 14, 2016·Bioorganic & Medicinal Chemistry Letters·Tatsunori SasakiKazuo Koike
Oct 4, 2011·Journal of Psychopharmacology·Mohammad NasehiMohammad Reza Zarrindast
May 17, 2018·Acta neurologica Belgica·Mohammad NasehiMohammad-Reza Zarrindast
Aug 4, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·A VakiliB Djahanguiri
Aug 30, 2014·Behavioural Pharmacology·Xiao-Yu BaiGuan-Hua Du

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