Step-forward randomization in multicenter emergency treatment clinical trials.

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
Wenle ZhaoYuko Y Palesch

Abstract

The authors present a new centralized randomization method for multicenter emergency treatment clinical trials. With this step-forward method, treatment randomization for the next subject is performed immediately after the enrollment of the current subject. This design ensures the readiness of the treatment assignment for each subject at the point of study enrollment, and it simultaneously provides effective control on treatment assignments balance and distributions of covariates. The authors also discuss procedures of the step-forward randomization method along with its implementation for two National Institute of Neurological Disorders and Stroke-funded multicenter acute stroke trials, one double-blinded and one open-labeled. Advantages and limitations are presented based on experience gained in these two trials.

References

May 1, 1974·Clinical Pharmacology and Therapeutics·D R Taves
Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
May 17, 2001·Emergency Medicine Journal : EMJ·B A Foëx
Jun 2, 2001·Journal of Clinical Psychopharmacology·K A KobakJ C Mundt
Feb 8, 2003·Stroke; a Journal of Cerebral Circulation·K R LeesUNKNOWN SA-NXY-0004 Investigators
Dec 29, 2005·Evidence-based Cardiovascular Medicine·L Friedman
Oct 3, 2006·Annals of Emergency Medicine·David W WrightDonald G Stein
Oct 27, 2007·Stroke; a Journal of Cerebral Circulation·John R Marler
Jun 3, 2008·Obstetrics and Gynecology·John E BusterCraig Peterson

❮ Previous
Next ❯

Citations

Dec 18, 2010·Stroke; a Journal of Cerebral Circulation·Myron D GinsbergUNKNOWN ALIAS Investigators
May 7, 2011·Stroke; a Journal of Cerebral Circulation·Michael D HillUNKNOWN Neurological Emergencies Treatment Trials Network
Jan 22, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Jeffrey L SaverUNKNOWN FAST-MAG Investigators and Coordinators
Sep 4, 2015·Research Synthesis Methods·Mark Stephen CorbettWilliam McGuire
Jul 17, 2013·Journal of Clinical Epidemiology·Jason T ConnorUNKNOWN ESETT and ADAPT-IT Investigators
Jul 28, 2016·Stroke; a Journal of Cerebral Circulation·Renee' H MartinUNKNOWN ALIAS Parts 1 and 2 and NETT Investigators
Nov 28, 2019·The New England Journal of Medicine·Jaideep KapurUNKNOWN NETT and PECARN Investigators

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.