Step length predicts executive dysfunction in Parkinson's disease: a 3-year prospective study

Journal of Neurology
Marianna AmboniPaolo Barone

Abstract

Cognition and gait appear to be closely related. The chronological interplay between cognitive decline and gait dysfunction is not fully understood. The aim of the present prospective study is investigating whether the dysfunction of specific gait parameters, during specific task and medication conditions, may predict subsequent cognitive impairment in Parkinson's disease (PD). We evaluated cognition and gait in 39 Parkinsonian patients at an initial assessment and after 3 years. Cognitive performance was evaluated with a neuropsychological battery designed to assess memory, executive/attention, and visuospatial domains. Gait was investigated using a gait analysis system during both the off and on states in the following conditions: (1) normal gait; (2) motor dual task; and (3) cognitive dual task. We used regression models to determine whether gait predicts subsequent cognitive dysfunction. Overall, the cognitive test scores were stable over time with the exception of the executive/attention scores, whereas all gait parameters declined. The step length during the cognitive dual task during the on state at the initial evaluation was the only significant predictor of executive/attention domain dysfunction at follow up. The resul...Continue Reading

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Citations

Jun 12, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Kaylena A Ehgoetz MartensSimon J G Lewis
Jun 29, 2021·Frontiers in Neurology·Marina PicilloMarianna Amboni
Jul 17, 2021·Brain Connectivity·Rosaria RuccoPierpaolo Sorrentino

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