STEP levels are unchanged in pre-frontal cortex and associative striatum in post-mortem human brain samples from subjects with schizophrenia, bipolar disorder and major depressive disorder

PloS One
Thomas A LanzDmitri Volfson

Abstract

Increased protein levels of striatal-enriched tyrosine phosphatase (STEP) have recently been reported in postmortem schizophrenic cortex. The present study sought to replicate this finding in a separate cohort of postmortem samples and to extend observations to striatum, including subjects with bipolar disorder and major depressive disorder in the analysis. No statistically significant changes between disease and control subjects were found in STEP mRNA or protein levels in dorsolateral prefrontal cortex or associative striatum. Although samples were matched for several covariates, postmortem interval correlated negatively with STEP protein levels, emphasizing the importance of including these analyses in postmortem studies.

References

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Citations

Apr 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Prajwal CiryamMichele Vendruscolo
Jul 28, 2016·Schizophrenia Bulletin·Yong WuXiong-Jian Luo
Feb 28, 2018·Nature Communications·Cui-Ping YangXiong-Jian Luo
Oct 19, 2019·Translational Psychiatry·Fedor E GusevEvgeny I Rogaev
Jun 27, 2018·Frontiers in Molecular Neuroscience·Anna A IgolkinaMaria G Samsonova
Jul 3, 2019·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lingfei LiuRanran Song
May 10, 2020·Human Genetics·Yong WuYong-Gang Yao
Feb 10, 2021·Neurochemical Research·Marloes VerkerkeJinte Middeldorp
Feb 7, 2021·Journal of Psychiatric Research·Brenda Cabrera-MendozaCristóbal Fresno

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Datasets Mentioned

BETA
GSE53987

Methods Mentioned

BETA
chip

Software Mentioned

NormFinder

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