Step response analyses of the cardiovascular system and their application to the measurement of systemic and pulmonary vein compliances

Heart and Vessels
A KamiyaH Shimazu

Abstract

A theoretical analysis of the step response in the closed cardiovascular system induced by a sudden shift of the right cardiac output curve predicted that if the relations of the right heart output (COr) and the total systemic capillary flow (CFs) to the systemic venous pressure (Psv) are linear, then the time course of Psv change will become monoexponential with a time constant T given by T = Csv/(Gr + Gs), where Csv is the systemic vein compliance and Gr and Gs are the conductances of the transient COr-Psv and CFs-Psv relationships. A similar prediction was obtained for the time constant T of the pulmonary vein pressure (Ppv) response to the step change in the left cardiac output (COl) curve, pulmonary vein compliance (Cpv) and the conductances of the COl curve, and the pulmonary capillary flow (CFp) curve against Ppv. The actual Psv or Ppv changes following sudden alteration of the COr or COl curve by inflation and deflation of the balloon in the right or left atrium revealed monoexponential time courses. Semilogarithmic plots of the transient vein pressure changes yielded correlation coefficients of -0.995 +/- 0.006 (means +/- SD) in 11 curves for Psv and 0.977 +/- 0.017 in 16 curves for Ppv (P less than 0.01). The assumed ...Continue Reading

References

Jan 1, 1976·Physiological Reviews·H R Kirchheim
Aug 1, 1975·Journal of Applied Physiology·W Mitzner, H Goldberg
Jul 1, 1973·Circulation Research·A A Shoukas, K Sagawa
Mar 1, 1974·Circulation Research·J A Drees, C F Rothe
Jan 1, 1971·British Heart Journal·B Folkow
Feb 1, 1971·Circulation Research·A A Shoukas, K Sagawa
Apr 1, 1971·Journal of Clinical Pathology·B G Woodhead, D S Ridley
Apr 1, 1968·Acta Physiologica Scandinavica·J Hadjiminas, B Oberg
Nov 1, 1968·The American Journal of Physiology·J IriuchijimaM F Wilson
Oct 22, 1983·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J E KusterE J Sanders

❮ Previous
Next ❯

Citations

Oct 3, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jian LiZai-Heng Zhang
Feb 14, 2007·Pflügers Archiv : European journal of physiology·Ian N SabirChristopher L-H Huang
May 27, 2006·Cardiology in the Young·Robert M FreedomRobert H Anderson
Mar 1, 1988·The Journal of Applied Bacteriology·C J Thomas, F Masters
Jan 1, 1988·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·R J CusimanoT A Salerno

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.