Stepping backward to improve assessment of PCB congener toxicities

Environmental Health Perspectives
L G Hansen

Abstract

Polychlorinated biphenyls (PCBs) are ubiquitous global contaminants that have been intensively investigated for three decades. They are broad-acting toxicants occurring in complex mixtures and accurate risk assessment has proven to be elusive. Focusing on a limited set of end points and emphasizing a fixed set of congeners have led to more streamlined data sets that are meant to expedite hazard characterization and risk assessment for the most potent congeners--aryl hydrocarbon receptor (AhR) agonists. Unfortunately, this has made it impossible to confirm or deny significant contributions from the more prevalent components of the mixtures. PCBs may be only coincidentally present, rather than causal, in some diseases. Still, attempts to determine associations with incomplete residue data may lead to erroneous conclusions and make accurate risk assessment even more elusive. Responses not mediated through the AhR are presented and emphasize large data gaps. Dissimilar analytical reports emphasize that selection of analytes is not consistent. Collectively, these data confirm that AhR-focused objectives unintentionally created the impression that nonplanar PCBs have little if any potential for hazards to humans and wildlife. Near st...Continue Reading

References

May 31, 1979·Annals of the New York Academy of Sciences·L G Hansen
May 31, 1979·Annals of the New York Academy of Sciences·J A Goldstein
Apr 1, 1977·Journal of Pharmaceutical Sciences·L G Hansen, M E Welborn
Aug 1, 1977·Clinical Pharmacology and Therapeutics·A P AlvaresA Kappas
Jan 1, 1992·Bulletin of Environmental Contamination and Toxicology·W M TehseenD J Schaeffer
Jan 1, 1992·Bulletin of Environmental Contamination and Toxicology·L G Hansen, E Storr-Hansen
Oct 1, 1991·Bulletin of Environmental Contamination and Toxicology·E DewaillyC Laliberté
Jan 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·A FaitE A Emmett
Sep 1, 1989·Archives of Environmental Contamination and Toxicology·T J KubiakT C Erdman
May 1, 1985·Environmental Health Perspectives·S SafeW Levin
Nov 1, 1988·Archives of Environmental Contamination and Toxicology·L Maack, W C Sonzogni
Nov 1, 1970·Journal of Agricultural and Food Chemistry·J Bitman, H C Cecil
Feb 1, 1982·Toxicology and Applied Pharmacology·M S WolffI J Selikoff
Oct 1, 1995·Archives of Environmental Contamination and Toxicology·L G HansenB Bush
Jul 1, 1994·Ecotoxicology and Environmental Safety·S A Saghir, L G Hansen
Apr 1, 1995·Bulletin of Environmental Contamination and Toxicology·M H Li, L G Hansen
Oct 1, 1994·Bulletin of Environmental Contamination and Toxicology·M H LiL G Hansen
Mar 1, 1994·Environmental Health Perspectives·J D McKinney, C L Waller

❮ Previous
Next ❯

Citations

Apr 15, 2010·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Sierra Rayne, Kaya Forest
Dec 12, 2013·Environmental Health : a Global Access Science Source·Zafar AminovUNKNOWN Anniston Environmental Health Research Consortium
Jul 6, 2014·Environment International·Jitender KumarErik Ingelsson
Jun 1, 2014·Environmental Science and Pollution Research International·Changjiang LiuKedi Yang
Jun 11, 2002·Environmental Health Perspectives·Rosette L Van Den HeuvelGreet E R Schoeters
Apr 5, 2003·Environmental Health Perspectives·Zhan-Fen QinXiao-Bai Xu
May 3, 2003·Environmental Health Perspectives·P Grace TeeSusan L Schantz
Jun 5, 2003·Environmental Health Perspectives·Lawrence M SchellUNKNOWN Akwesasne Task Force on the Environment
Feb 5, 2000·Environmental Health Perspectives·H E HumphreyS L Schantz
Feb 9, 2002·Environmental Health Perspectives·David O CarpenterDavid C Spink
Dec 19, 2001·Environmental Health Perspectives·S L Schantz, J J Widholm
Jul 11, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Martin Van den BergRichard E Peterson
Nov 17, 2006·Journal of Epidemiology and Community Health·Duk-Hee LeeMiquel Porta
Apr 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·T KenetM M Merzenich
Feb 22, 2008·Environmental Health Perspectives·Edward F FitzgeraldHeraline E Hicks
Oct 23, 2008·Human Reproduction·G M Buck LouisJ E Vena
Jun 9, 2009·Endocrine Reviews·Evanthia Diamanti-KandarakisAndrea C Gore
Oct 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S M Rhind
Apr 14, 2010·Environmental Science & Technology·Tomás TrnovecSona Wimmerová
Jul 27, 2005·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Kazuhiko AkutsuShinjiro Hori
Oct 20, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Bei ZhangMichal Toborek
Dec 9, 2003·Chemosphere·Elena De FelipLeopoldo Silvestroni
Jan 7, 2016·Environment International·Ling LengNai-Jun Tang
Jan 30, 2015·Critical Reviews in Toxicology·Fabian A GrimmLarry W Robertson
Apr 19, 2011·Ecotoxicology and Environmental Safety·Jiang WuXiaodong Han
Feb 8, 2011·Reproductive Toxicology·Barbara A CohnPamela J Schwingl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.