Steps Toward High-Performance PLA: Economical Production of d-Lactate Enabled by a Newly Isolated Sporolactobacillus terrae Strain

Biotechnology Journal
Xiao HanFei Tao

Abstract

Optically pure d-lactate production has received much attention for its critical role in high-performance polylactic acid production. However, the current technology can hardly meet the comprehensive demand of industrialization on final titer, productivity, optical purity, and raw material costs. Here, an efficient d-lactate producer strain, Sporolactobacillus terrae (S. terrae) HKM-1, is isolated for d-lactate production. The strain HKM-1 shows extremely high d-lactate fermentative capability by using peanut meal, soybean meal, or corn steep liquor powder as a sole nitrogen source; the final titers (205.7 g L-1 , 218.9 g L-1 , and 193.9 g L-1 , respectively) and productivities (5.56 g L-1  h-1 , 5.34 g L-1  h-1 , and 3.73 g L-1  h-1 , respectively) of d-lactate reached the highest level ever reported. A comparative genomic analysis between S. terrae HKM-1 and previously reported d-lactate high-producing Sporolactobacillus inulinus (S. inulinus) CASD is conducted. The results show that many unrelated genetic features may contribute to the superior performance in d-lactate production of S. terrae HKM-1. This d-lactate producer HKM-1, along with its fermentation process, is promising for sustainable d-lactate production by using ...Continue Reading

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