Stepwise control of host-guest interaction using a coordination polymer gel

Nature Communications
Rahul Dev MukhopadhyayAyyappanpillai Ajayaghosh

Abstract

Precise control of host-guest interaction as seen in biological processes is difficult to achieve with artificial systems. Herein we have exploited the thermodynamic benefits of a system in equilibrium to achieve controlled stepwise release and capture of cyclodextrin (guest) using a coordination polymer (Mg-CP) as the host and temperature as the stimulus. Since temperature is not a precision stimulus for artificial host-guest interaction, the present system is a distinct prototype that manifests temperature-controlled natural host-guest interaction. The described coordination polymeric host system, when incorporated into a hydrogel matrix, provides a microenvironment that facilitates the stepwise release of α-CD in response to temperature variation within a quasi-solid state. The work demonstrated here may pave the way towards thermally controlled delivery and monitoring of otherwise spectroscopically silent molecules such as cyclodextrins.

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Citations

Jun 5, 2018·Chemistry, an Asian Journal·Protap BiswasParthasarathi Dastidar
Oct 20, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Konstantina PringouriJeremy M Rawson
Feb 13, 2019·Chemical Science·Kalathil K KarthaGustavo Fernández
Oct 30, 2020·Chemical Society Reviews·Li ZhangMinghua Liu
Feb 6, 2020·International Journal of Biological Macromolecules·Xiaojun WuJunjie Li
Dec 16, 2021·Chemical Communications : Chem Comm·Yeeshu Kumar, Mrigendra Dubey

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Methods Mentioned

BETA
circular dichroism
nuclear magnetic resonance
X-ray
electron diffraction

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