Stepwise lineage restriction of progenitors in lympho-myelopoiesis

International Reviews of Immunology
Y Katsura, Hiroshi Kawamoto

Abstract

It has long been controversial whether hematopoiesis progresses through ordered stages of determination as in embryonic development. This is due to the absence of a methodology capable of exactly determining the developmental potential of hematopoietic stem/progenitor cells. The multilineage progenitor (MLP) assay enabled us to discriminate among seven types of hematopoietic progenitors, which are multipotent progenitor p-MTB (capable of generating myeloid, T and B cells), bipotent progenitors p-MT, p-MB and p-TB, and unipotent progenitors p-M, p-T and p-B. Among these seven types, the p-TB type progenitor was found to be absent. These findings indicate that the process of lineage commitment proceeds through an ordered but not random process. By extending the area of investigation to include the erythroid lineage, more convincing evidence for the ordered process was obtained. Detailed and exact illustration of the process of hematopoiesis will provide an opportunity to revive hematopoiesis as one of the most fascinating targets of research in developmental biology.

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Citations

Nov 26, 2002·Immunological Reviews·Jun HirosePaul W Kincade
Jan 8, 2010·International Immunology·Hiroshi KawamotoYoshimoto Katsura
Jul 3, 2010·Science·Tomokatsu IkawaHiroshi Kawamoto
Feb 7, 2012·Blood·Anna Bigas, Lluis Espinosa
Jan 30, 2014·Annual Review of Immunology·Ellen V Rothenberg
Nov 26, 2013·Experimental Hematology·Hideo EmaToshio Suda
Oct 26, 2010·Immunological Reviews·Hiroshi KawamotoYoshimoto Katsura
Oct 26, 2010·Immunological Reviews·Sasan ZandiMikael Sigvardsson
Apr 19, 2016·Immunological Reviews·Ellen V RothenbergJingli A Zhang
Mar 26, 2002·Nature Reviews. Immunology·Yoshimoto Katsura
Feb 2, 2006·Immunological Reviews·Elizabeth-Sharon David-FungEllen V Rothenberg
Oct 17, 2017·The EMBO Journal·Llucia Alberti-ServeraAntonius Rolink
Oct 9, 2002·Immunological Reviews·Ellen V Rothenberg, Christopher J Dionne
Oct 9, 2002·Immunological Reviews·Paul W KincadeMaria Isabel D Rossi
Jan 25, 2005·Shock·John G NoelCora K Ogle
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min LuYoshimoto Katsura
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susan E ProckopHoward T Petrie

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