Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization.

Biochimica Et Biophysica Acta
Jiahn-Dar HuangIgnacio R Rodriguez

Abstract

Sterculic acid is a cyclopropene fatty acid with numerous biological activities. In this study we demonstrate that sterculic acid is a potent inhibitor of endoplasmic reticulum (ER) stress and related inflammation caused by 7-ketocholesterol (7KCh). 7KCh is a highly toxic oxysterol suspected in the pathogenesis of various age-related diseases such as atherosclerosis, Alzheimer's disease and age-related macular degeneration. Sterculic acid demonstrated to be 5-10 times more effective than other anti-inflammatory fatty acids at inhibiting 7KCh-mediated inflammatory responses in cultured cells. In vivo, sterculic acid was effective at inhibiting the formation of choroidal neovascularization (CNV) in the laser-injury rat model. Our data suggests that sterculic acid may be useful in treating CNV in certain forms of age-related macular degeneration.

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Citations

Feb 15, 2013·PloS One·Juan AmaralIgnacio R Rodríguez
May 6, 2014·Experimental Eye Research·Sarah X ZhangJoshua J Wang
Oct 12, 2014·Ageing Research Reviews·Amira ZarroukGérard Lizard
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