Stereocomplex Film Using Triblock Copolymers of Polylactide and Poly(ethylene glycol) Retain Paxlitaxel on Substrates by an Aqueous Inkjet System

Langmuir : the ACS Journal of Surfaces and Colloids
Hiroharu AjiroMitsuru Akashi

Abstract

The stereocomplex formation of poly(L,L-lactide) (PLLA) and poly(D,D-lactide) (PDLA) using an inkjet system was expanded to the amphiphilic copolymers, using poly(ethylene glycol) (PEG) as a hydrophilic polymer. The diblock copolymers, which are composed of PEG and PLLA (MPEG-co-PLLA) and PEG and PDLA (MPEG-co-PDLA), were employed for thin-film preparation using an aqueous inkjet system. The solvent and temperature conditions were optimized for the stereocomplex formation between MPEG-co-PLLA and MPEG-co- PDLA. As a result, the stereocomplex was adequately formed in acetonitrile/water (1:1, v/v) at 40 °C. The aqueous conditions improved the stereocomplex film preparation, which have suffered from clogging when using the organic solvents in previous work. The triblock copolymers, PLLA-co-PEG-co-PLLA and PDLA-co-PEG-co-PDLA, were employed for square patterning with the inkjet system, which produced thin films. The amphiphilic polymer film was able to retain hydrophobic compounds inside. The present result contributed to the rapid film preparation by inkjet, retaining drugs with difficult solubility in water, such as paclitaxel within the films.

References

Mar 17, 2001·Advanced Drug Delivery Reviews·K KataokaY Nagasaki
Jan 16, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shaobing ZhouHeming Li
Nov 11, 2003·Biomacromolecules·Ann-Christine Albertsson, Indra K Varma
Feb 10, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·K C KrogmanP T Hammond
Mar 7, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chaoliang HeDoo Sung Lee
Aug 30, 2008·Chemical Communications : Chem Comm·Tran Hang ThiMitsuru Akashi
Mar 11, 2010·Advanced Materials·Madhusudan SinghGhassan E Jabbour
Apr 13, 2010·Biomaterials·Tingfei XiShengping Zhong
Jul 20, 2011·Journal of Polymer Science. Part B, Polymer Physics·Bret D UleryCato T Laurencin
May 10, 2012·ACS Applied Materials & Interfaces·Rattanon SuntivichVladimir V Tsukruk
Nov 28, 2012·Advanced Healthcare Materials·Michiya MatsusakiMitsuru Akashi
Nov 28, 2013·Lab on a Chip·Sebastian WünscherUlrich S Schubert
Jan 28, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Takami AkagiMitsuru Akashi
Mar 13, 2014·Biomacromolecules·Rattanon SuntivichVladimir V Tsukruk
Dec 9, 2014·Advanced Materials·David StüweJan G Korvink
Apr 14, 2015·Angewandte Chemie·Kentaro YamadaDaniel Citterio
Apr 25, 2015·Science·Joseph J RichardsonFrank Caruso

❮ Previous
Next ❯

Citations

Jul 20, 2016·Advanced Drug Delivery Reviews·Arijit BasuWahid Khan
Aug 31, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Hiroharu AjiroKazue Kurihara
Sep 13, 2017·Macromolecular Rapid Communications·Hongwei BaiQiang Fu
Dec 15, 2016·Chemical Reviews·Joseph J RichardsonFrank Caruso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.