Stereocomplexed micelle formation through enantiomeric PLA-based Y-shaped copolymer for targeted drug delivery

Materials Science & Engineering. C, Materials for Biological Applications
Wenqiang LiZibiao Li

Abstract

In this study, a novel stereocomplexed micelle system was prepared from the self-assembly of enantiomeric PLA-based Y-shaped copolymers, i.e. folic acid-adamantane/β-cyclodextrin-b-[poly(D-lactide)]2 (FA-AD/CD-b-(PDLA)2) and poly(2-dimethylaminoethyl methacrylate)-b-[poly(L-lactide)]2 (PDMAEMA-b-(PLLA)2) in aqueous solution. The newly designed Y-shaped copolymer FA-AD/CD-b-(PDLA)2 was prepared by a combination of "click" reaction and host guest interaction between FA-AD and CD-b-(PDLA)2. In addition, enantiomeric Y-shaped PDMAEMA-b-(PLLA)2 copolymer was synthesized through ring-opening polymerization (ROP) of L-lactide using three-head initiator with bromo and -OH at distal ends, followed by atom transfer radical polymerization (ATRP) of DMAEMA to obtain the desired macromolecular architecture. The resultant copolymers and their intermediates were characterized by 1H nuclear magnetic resonance (1H NMR) and gel permeation chromatography (GPC) techniques. Due to the strong stereocomplexation interaction, FA-AD/CD-b-(PDLA)2 and PDMAEMA-b-(PLLA)2 mixture could self-assemble into stable mixed micelles in aqueous solution. Further, the stereocomplexed micelles exhibited excellent biocompatibility as revealed in the cytotoxicity assay...Continue Reading

Citations

Sep 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xuan LiuZibiao Li
Sep 26, 2020·Journal of Functional Biomaterials·Bahareh AzimiSerena Danti
Jul 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Kowalewska, Maria Nowacka
Aug 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bartłomiej KostTadeusz Biela
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Qiankun JiangJing Li
Apr 20, 2021·Macromolecular Bioscience·Xiaoshan FanZibiao Li
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seung Hyuk ImSoo Hyun Kim

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