Stereological analysis of the rhesus monkey entorhinal cortex

The Journal of Comparative Neurology
Olivia PiguetPierre Lavenex

Abstract

The entorhinal cortex is a prominent structure of the medial temporal lobe, which plays a pivotal role in the interaction between the neocortex and the hippocampal formation in support of declarative and spatial memory functions. We implemented design-based stereological techniques to provide estimates of neuron numbers, neuronal soma size, and volume of different layers and subdivisions of the entorhinal cortex in adult rhesus monkeys (Macaca mulatta; 5-9 years of age). These data corroborate the structural differences between different subdivisions of the entorhinal cortex, which were shown in previous connectional and cytoarchitectonic studies. In particular, differences in the number of neurons contributing to distinct afferent and efferent hippocampal pathways suggest not only that different types of information may be more or less segregated between caudal and rostral subdivisions, but also, and perhaps most importantly, that the nature of the interaction between the entorhinal cortex and the rest of the hippocampal formation may vary between different subdivisions. We compare our quantitative data in monkeys with previously published stereological data for the rat and human, in order to provide a perspective on the relat...Continue Reading

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Citations

Apr 22, 2020·Journal of Anatomy·José Carlos Delgado-GonzálezEmilio Artacho-Pérula
Mar 7, 2020·The Journal of Comparative Neurology·Olivia PiguetPierre Lavenex
Nov 26, 2019·The Journal of Comparative Neurology·Paulo L A de Góis MoraisExpedito S Nascimento Junior
Jun 15, 2021·Frontiers in Psychiatry·Pamela Banta Lavenex, Pierre Lavenex
Jul 3, 2021·International Journal of Molecular Sciences·Loïc J ChareyronPierre Lavenex

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