Stereological approaches to dementia research using human brain tissue

Journal of Chemical Neuroanatomy
D Erskine, A A Khundakar

Abstract

The relationship between the clinical features of dementia disorders and the resultant changes in underlying neuropathological mechanisms has long been of interest to researchers working in the field of neurodegenerative disorders. The majority of neuropathological research in dementia has utilized semi-quantitative analysis of protein inclusions, which have defined the hallmark histological features of the conditions. However, the advent of three-dimensional stereological techniques has enabled unbiased and fully quantitative assessment of brain tissue. The present review focuses on studies that have used these techniques to elucidate important relationships between neuropathological changes and clinical features and, in doing so, revealed important mechanistic insights into the pathophysiology of dementia disorders.

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Citations

Jul 22, 2017·Journal of Chemical Neuroanatomy·Kristian H Reveles Jensen, Rune W Berg
Jul 11, 2020·Acta Neuropathologica Communications·Christopher HattonDaniel Erskine

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