Stereological studies on the epiphyseal growth cartilage and characterization of costal cartilage proteoglycans in the achondroplastic (cn/cn) mouse

Collagen and Related Research
B WikströmB Engfeldt

Abstract

The achondroplastic mouse is a dwarf mouse in which the endochondral growth of the skeleton is disturbed. The main morphological characteristic of the affected growth cartilage is an underdeveloped hypertrophic zone. The pattern of matrix mineralization seems to be unaffected, even in areas where hypertrophic chondrocytes are completely absent. The present stereological results indicate a disturbance of the cn/cn cartilage already in the proliferative zone. At the electron microscopical level a clearly abnormal spatial distribution of matrix vesicles was observed in the affected growth cartilage. The vesicle concentration of the cn/cn cartilage was increased, but the mineralizing cartilage showed a decrease of vesicles similar to that in the normal tissue. Parallel biochemical characterization of the proteoglycans and glycosaminoglycans of the cn/cn costal cartilage revealed normal conditions, also in the growth region, which was sampled as a separate tissue fraction. Thus the biochemical results provide no evidence of disturbed glycosaminoglycan metabolism.

References

Sep 8, 1975·Biochimica Et Biophysica Acta·S Lohmander, A Hjerpe
Mar 1, 1985·Collagen and Related Research·B WikströmA Hjerpe
Sep 1, 1967·Journal of Ultrastructure Research·E Bonucci
Nov 1, 1974·Archives of Biochemistry and Biophysics·D Heinegård, V C Hascall
May 1, 1970·Transactions of the New York Academy of Sciences·H C AndersonS Y Ali
Jan 1, 1970·Zeitschrift für Zellforschung und mikroskopische Anatomie·E Bonucci
Apr 1, 1969·The Journal of Cell Biology·H C Anderson
Jan 1, 1983·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·F P ReinholtB Engfeldt
Apr 1, 1982·The Journal of Bone and Joint Surgery. American Volume·A FranzénS E Olsson
Feb 1, 1982·Analytical Biochemistry·A FranzénD Heinegård
Jan 1, 1977·Upsala Journal of Medical Sciences·D S Howell, J C Pita

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Citations

Jul 28, 2009·Seminars in Thoracic and Cardiovascular Surgery·Alexander A FokinKaren E Allen

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