PMID: 43016Jan 1, 1979

Stereological study of B-cell mitochondria in alloxan-treated mice

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
R Lorentzon, L Boquist

Abstract

Using stereological techniques, including semi-automatic image analysis, the B-cell mitochondria were studied in the pancreatic islets from one group of control mice and two groups of mice killed 10 min and 60 min, respectively, after alloxan administration. Ten min following alloxan the mitochondrial volume and envelope surface densities, the mean mitochondrial volume and surface area, and the area of mitochondrial profiles were significantly increased, whereas the mitochondrial numerical density was not significantly altered. At the 60 min observation time the mitochondrial volume density, the mean mitochondrial volume and surface areas, and the area of mitochondrial profiles were significantly decreased, whereas the mitochondrial envelope surface was not significantly altered. The findings indicate a rapid swelling, followed by disintegration of the mitochondria in the B-cells of alloxan-treated mice, thereby supporting our view that mitochondrial lesions play a primary role in the development of alloxan diabetes. These lesions are believed to be due to ionic alterations in the B-cells ("Pi-pH hypothesis").

Citations

Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·R NorlundI B Täljedal
Apr 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Brad J MarshKathryn E Howell
Jan 1, 1979·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·L Boquist, R Lorentzon
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P Flament, C Remacle
Jan 1, 1981·Upsala Journal of Medical Sciences·L Boquist, L Nelson
May 1, 1981·The American Journal of Anatomy·T Sato, L Herman
Nov 12, 1981·Nature·K GrankvistI B Täljedal
Jul 1, 1982·Histopathology·G AntonakopoulosM Wilkinson
Jul 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·R LorentzonL Boquist
Jul 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·R LorentzonL Boquist
Jul 1, 1980·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·L Boquist

Related Concepts

Alloxan
Streptozotocin Diabetes
Islets of Langerhans
Mitochondria
Mitochondrial Swelling

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