PMID: 43017Jan 1, 1979

Stereological study of endoplasmic reticulum, Golgi complex and secretory granules in the B-cells of normal and alloxan-treated mice

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
L Boquist, R Lorentzon

Abstract

Different B-cell organelles (lamellar and vesicular endoplasmic reticulum, Golgi complex, whole secretory granules and secretory granule cores) were studied stereologically in pancreatic islets from control mice and mice killed 10 or 60 min following alloxan injection. Ten min following alloxan a significant decrease was observed in the volume, surface and numerical densities of whole secretory granules and their cores, and a significant increase was found in the volume and surface densities of vesicular endoplasmic reticulum. At the 60 min observation time, a significant decrease was seen in the volume density of lamellar endoplasmic reticulum and Golgi complex, and in the volume, surface and numerical densities of whole secretory granules and their cores, and a significant increase was observed in the volume and surface densities of vesicular endoplasmic reticulum, and in the mean values for volume and surface of whole secretory granules and their cores. The stereological data indicate swelling of endoplasmic reticulum, decreased Golgi area, and decreased number and total volume and surface of secretory granules during the first hour after alloxan administration to mice. The observations may be consistent with inhibited insul...Continue Reading

References

Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·R NorlundI B Täljedal
Jan 1, 1986·The International Journal of Biochemistry·K Grankvist, S L Marklund
Apr 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Brad J MarshKathryn E Howell
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P Flament, C Remacle
May 1, 1981·The American Journal of Anatomy·T Sato, L Herman
Jul 25, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Henri J HuttunenDora M Kovacs
Jul 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·R LorentzonL Boquist
Jul 1, 1980·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·L Boquist

Citations

Jan 1, 1979·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R Lorentzon, L Boquist
Sep 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·P K DixitR E Hernandez
Nov 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R Gunnarsson, C Hellerström
Jan 1, 1969·International Review of Cytology·E R Weibel
Jul 1, 1966·The Journal of Cell Biology·E R WeibelW F Scherle
Oct 1, 1967·European Journal of Pharmacology·I Lundquist, C Rerup

Related Concepts

Golgi Apparatus
B-Lymphocytes
Streptozotocin Diabetes
Electron Microscopy
Alloxan
Insulin Biosynthetic Process
Islets of Langerhans
Congenital Lamellar Cataract
Edema
Secretory Vesicles

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