Stereological study of stage 34 chicken hearts with looping disturbances after retinoic acid treatment: disturbed growth of myocardium and atrioventricular cushion tissue

The Anatomical Record
H G BoumanA C Wenink

Abstract

In a previous study retinoic acid treatment of chicken hearts has resulted in a spectrum of looping disturbances. Because of a decrease in contraction force of these hearts, the myocardial volume was hypothesized to be altered. Because retinoic acid has been suggested to influence endocardial cushion volumes, these were estimated as well. The previously studied hearts were used for estimating the absolute volumes of the atrial and ventricular myocardium and of the endocardial cushions by means of Cavalieri's principle. To measure the surface density of the trabeculations according to the isector method, we used retinoic acid treated hearts, which were perfusion fixed and in which the sections were isotropic uniform random. The volumes and surface densities found in the three morphologically distinguished groups, i.e., intact septum, isolated ventricular septal defect and double outlet right ventricle, were compared with those in shams. A significant volume decrease was found in the right ventricular free wall myocardium of the double outlet right ventricle. No significant differences were found in the surface densities of the trabeculae. The volume of the atrioventricular cushion tissue in the double outlet right ventricle hear...Continue Reading

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Citations

Jun 30, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Brad J Martinsen
Sep 11, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H G BoumanA C Wenink
Nov 25, 2005·Pediatric Research·Mireille N BekkerAdriana C Gittenberger-de Groot
Mar 29, 2000·The Anatomical Record·D SedmeraR H Anderson
Jul 29, 2008·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Jörg Männer
Jul 23, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mohamad AzharThomas Doetschman
Sep 26, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Margaret L Kirby
Dec 4, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Daniël G M MolinAdriana C Gittenberger-De Groot
Jul 18, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Daria CipolloneBruno Marino

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