Jan 1, 1989

Stereological study of the developing distal femoral growth plate

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
L LippielloJ F Connolly

Abstract

The distal femoral growth plate has a uniquely convoluted structure comprised of four mammillate processes. Factors contributing to the development of these processes and overall plate geometry were explored using three-dimensional image analysis of the canine distal femoral epiphysis. The growth plate at birth remains relatively flat until ossification of the epiphysis begins at 1 week of age. Epiphyseal ossification proceeds eccentrically, projecting in the medial-lateral and anterior-posterior directions. Growth plate activity indexed by [3H]thymidine labeling and plate thickness revealed regional differences in cell proliferation. This was measured as a decreased labeling index and thinning of the growth plate in areas capped by the ossifying epiphysis. The eccentric ossification pattern and associated variations in growth plate activity result in definition of an "intraphyseal" groove and medial-lateral oriented sulcus. The groove and sulcus bisect the plate into four quadrants, giving rise to a convoluted structure composed of four areas of plate elevations termed mammillary processes (MP). By 5 weeks, the pattern of ossification results in greater development of the MP in the anterior-medial quadrant and in decreasing or...Continue Reading

  • References8
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References

  • References8
  • Citations8

Citations

Mentioned in this Paper

Groove
Plasma Cell Labeling Index
Thymidine
Epiphysis Disorders
Slipped Capital Femoral Epiphyses
Cell Proliferation
Epiphysis of Bone
Body Surface Area Formula for Dogs
Tomography, X-Ray Computerized Axial
Autoradiography

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