PMID: 16509309Mar 3, 2006Paper

Stereoselective degradation kinetics of theta-cypermethrin in rats

Environmental Science & Technology
Qiuxia WangZhiqiang Zhou

Abstract

The enantioselective degradation and chiral conversion of theta-cypermethrin (TCYM) in rats have been studied via intravenous (i.v.) injection. The degradation kinetics and the enantiomer fraction (EF) were determined by means of normal-phase high-performance liquid chromatography (HPLC) with diode array detection (DAD) and a cellulosetris-(3,5-dimethylphenylcarbamate)-based chiral stationary phase (CDMPC-CSP). The degradation followed pseudo-first-order kinetics. The degradation of the (+)-TCYM was much faster than that of the (-)-TCYM in plasma, heart, liver, kidney, and fat after administration of racemic TCYM (rac-TCYM). The EFs were over 0.500 in these tissues and muscle. The results showed the conversion of (+)-enantiomer to (-)-enantiomer in plasma after injection of (-)- and (+)-TCYM separately. The results for the major differences in the degradation of the enantiomers may have some implication for the environmental and ecological risks assessment for chiral pesticides.

Citations

May 18, 2010·Journal of the Science of Food and Agriculture·Hua KuangYongning Wu
Feb 22, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ping ZhangZhiqiang Zhou
Jul 30, 2014·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Fang QinHui L Wang
Nov 5, 2016·Toxicology and Applied Pharmacology·Virginia C MoserKatherine L McDaniel
Jan 24, 2017·Environmental Toxicology and Chemistry·Ye YangJing Liu
May 23, 2006·Analytical and Bioanalytical Chemistry·Charles S Wong
Nov 23, 2006·Chirality·Wentao ZhuZhiqiang Zhou
Jan 1, 2020·Environmental Science and Pollution Research International·Zikang WangZhiqiang Zhou
Jun 26, 2009·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·W ZhuZ Zhou
Aug 30, 2013·Environmental Science & Technology·Juying LiZhong Li

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