PMID: 9523816Apr 2, 1998Paper

Stereoselective differences in the vasorelaxing effects of S(+) and R(-) ketamine on rat isolated aorta

Anesthesiology
A KanellopoulosB Mühlbauer

Abstract

S(+) ketamine, because of its higher anesthetic potency and lower risk of psychotomimetic reactions, has been suggested to be superior to presently available racemic ketamine. The racemate is a direct vasodilator in vivo, and thus the authors investigated the vasorelaxing effects of ketamine enantiomers on rat aorta. Rat isolated aortic rings with and without endothelium were contracted with 3 x 10(-7) M norepinephrine. Then 10(-5) to 3 x 10(-3) M S(+), R(-), or racemic ketamine were added cumulatively. Vascular responses to ketamine were further studied in rings pretreated with the nitric oxide synthase inhibitor N(omega)-nitro-L-arginine (NNLA), the adenosine triphosphate-sensitive K+ channel antagonist glibenclamide, and the L-type calcium channel blocking agent D888. Ketamine enantiomers and the racemate produced concentration-dependent vasorelaxation. The relaxing effect of S(+) ketamine was significantly weaker compared with R(-) ketamine and the racemate reflected by the half-maximum effective concentration (EC50) values of 11.6 x 10(-4), 4.8 x 10(-4), and 6 x 10(-4) M, respectively. Removal of the endothelium and NNLA or glibenclamide pretreatment did not significantly alter the vasorelaxing effect of ketamine. In contr...Continue Reading

References

May 1, 1978·European Journal of Pharmacology·S RyderA J Trevor
Jul 15, 1987·Biochemical and Biophysical Research Communications·H Schmid-AntomarchiM Lazdunski
Sep 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A P Somlyo, B Himpens
Jun 1, 1989·British Journal of Pharmacology·Y KanmuraR Casteels
Sep 1, 1987·British Journal of Pharmacology·C DacquetJ Mironneau
Feb 1, 1985·British Journal of Anaesthesia·P F WhiteA J Trevor
Nov 1, 1974·Anesthesia and Analgesia·A D IvankovichB Zahed
Nov 1, 1983·Circulation Research·R F Furchgott
Jun 1, 1983·Anesthesia and Analgesia·S FukudaN Toda
Mar 1, 1980·Anesthesiology·P F WhiteA J Trevor
Oct 1, 1980·British Journal of Pharmacology·B M AlturaA Carella
Jun 4, 1993·European Journal of Pharmacology·P H RatzF A Lattanzio
Jan 1, 1995·Pharmacology & Toxicology·M YamazakiY Ito
Jul 11, 1994·European Journal of Pharmacology·P E Light, R J French
Nov 1, 1996·Anesthesia and Analgesia·Y KanmuraR Casteels

❮ Previous
Next ❯

Citations

Jul 23, 2005·Anesthesia and Analgesia·Sabine Himmelseher, Marcel E Durieux
Jan 23, 2016·Anesthesia and Analgesia·José A AguirreMichael Zaugg
Apr 1, 2004·Veterinary Anaesthesia and Analgesia·Deborah V WilsonDavid R Mullineaux
Apr 28, 2005·European Journal of Anaesthesiology·A P Klockgether-RadkeG Hellige
Dec 13, 2007·Anesthesiology·Noboru TodaYoshio Hatano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.