Stereoselective effect of (R)- and (S)-1-methyl-1,2,3,4-tetrahydroisoquinolines on a mouse model of Parkinson's disease

Brain Research Bulletin
K AbeT Sano

Abstract

We carried out behavioral, pathological, and biochemical studies in order to determine whether the stereo-structure of 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ) affects the onset of Parkinson's disease-like symptoms, which are induced by 1,2,3,4-tetrahydroisoquinoline (TIQ) in mice. Pretreatment with (R)-1-MeTIQ or its racemate (RS)-1-MeTIQ prevented the TIQ-induced bradykinesia. Pretreatment with a combination of L-DOPA and carbidopa significantly prevented subsequent TIQ-induced bradykinesia. Furthermore, the pathological study demonstrated that either (R)-1-MeTIQ or its racemate protected against TIQ-induced loss of tyrosine hydroxylase-positive cells of the substantia nigra pars compacta. (R)-1-MeTIQ and its racemate also prevented the TIQ-induced reduction in the levels of dopamine and its metabolites in the striatum. Serotonin and its metabolite were not affected by repeated administration of (RS)-1-MeTIQ or its derivatives. On the other hand, (S)-1-MeTIQ induced moderate but significant bradykinesia, whereas (R)-1-MeTIQ did not induce this behavioral abnormality at all. In addition, (S)-enantiomer prevented the onset of TIQ-induced bradykinesia, though to a lesser extent than did either (R)-enantiomer or its race...Continue Reading

References

Apr 29, 1987·Biochemical and Biophysical Research Communications·T NiwaT Nagatsu
Oct 15, 1986·Biochemical and Biophysical Research Communications·M KohnoM Hirobe
Sep 1, 1996·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·K S McNaughtC D Marsden
Jan 4, 2001·Brain Research Bulletin·M Drobný, E Kurca

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Citations

Aug 5, 2005·Biological & Pharmaceutical Bulletin·Kenji AbeKyoji Taguchi
Jul 5, 2006·Biological & Pharmaceutical Bulletin·Katsuhiro OkudaShigeru Ohta
Mar 1, 2005·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Zhe QuanYi-Ming Liu
Aug 26, 2015·Neurotoxicity Research·Agnieszka WąsikLucyna Antkiewicz-Michaluk
Oct 23, 2012·Pharmacological Reports : PR·Agnieszka WąsikLucyna Antkiewicz-Michaluk
Jun 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Erwan Bezard, Serge Przedborski
Jun 18, 2017·Pharmacological Reports : PR·Agnieszka Wąsik, Lucyna Antkiewicz-Michaluk

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