Abstract
We carried out behavioral, pathological, and biochemical studies in order to determine whether the stereo-structure of 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ) affects the onset of Parkinson's disease-like symptoms, which are induced by 1,2,3,4-tetrahydroisoquinoline (TIQ) in mice. Pretreatment with (R)-1-MeTIQ or its racemate (RS)-1-MeTIQ prevented the TIQ-induced bradykinesia. Pretreatment with a combination of L-DOPA and carbidopa significantly prevented subsequent TIQ-induced bradykinesia. Furthermore, the pathological study demonstrated that either (R)-1-MeTIQ or its racemate protected against TIQ-induced loss of tyrosine hydroxylase-positive cells of the substantia nigra pars compacta. (R)-1-MeTIQ and its racemate also prevented the TIQ-induced reduction in the levels of dopamine and its metabolites in the striatum. Serotonin and its metabolite were not affected by repeated administration of (RS)-1-MeTIQ or its derivatives. On the other hand, (S)-1-MeTIQ induced moderate but significant bradykinesia, whereas (R)-1-MeTIQ did not induce this behavioral abnormality at all. In addition, (S)-enantiomer prevented the onset of TIQ-induced bradykinesia, though to a lesser extent than did either (R)-enantiomer or its race...Continue Reading
References
Dec 1, 1991·Journal of Neurochemistry·Y TasakiM Hirobe
Oct 30, 1990·Neuroscience Letters·M YoshidaT Nagatsu
Dec 1, 1990·Journal of Neurochemistry·A H SchapiraC D Marsden
Jul 1, 1990·Biomedical & Environmental Mass Spectrometry·Y MakinoM Hirobe
Apr 9, 1985·Neuroscience Letters·M A Collins, E J Neafsey
Jan 1, 1985·Neuropharmacology·F HeftiE Melamed
Apr 29, 1987·Biochemical and Biophysical Research Communications·T NiwaT Nagatsu
Oct 15, 1986·Biochemical and Biophysical Research Communications·M KohnoM Hirobe
Dec 1, 1985·Journal of Neurochemistry·C Mytilineou, G Cohen
Feb 25, 1983·Science·J W LangstonI Irwin
Oct 26, 1993·European Journal of Pharmacology·R M WuD L Murphy
Apr 30, 1993·Brain Research·K MatsubaraH Shiono
Dec 1, 1995·Neurology·K MatsubaraK Kimura
Sep 1, 1996·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·K S McNaughtC D Marsden
Oct 6, 1997·Neuroscience Letters·W MaruyamaM Naoi
Feb 20, 1999·Neuroscience Letters·T Yamakawa, S Ohta
Apr 1, 1999·Neurochemistry International·T A Reader, K M Dewar
Dec 10, 1999·Neuroscience Letters·T YamakawaS Ohta
Feb 22, 2000·Neuroscience·E Lorenc-KociS Wolfarth
Feb 23, 2000·Neuroscience·L Antkiewicz-MichalukA Szczudlik
Jun 15, 2000·Journal of Neurochemistry·J ParradoA Machado
Jan 4, 2001·Brain Research Bulletin·M Drobný, E Kurca
Feb 28, 2001·Brain Research Bulletin·M TariqS Al Deeb
Citations
Jul 2, 2003·Neurotoxicity Research·T PalomoT Archer
Nov 12, 2010·Neurotoxicity Research·Lucyna Antkiewicz-MichalukJerzy Michaluk
Aug 5, 2005·Biological & Pharmaceutical Bulletin·Kenji AbeKyoji Taguchi
Jul 5, 2006·Biological & Pharmaceutical Bulletin·Katsuhiro OkudaShigeru Ohta
Feb 6, 2004·Chemical & Pharmaceutical Bulletin·Yoshie HoriguchiTakehiro Sano
May 31, 2013·Neurotoxicity Research·Lucyna Antkiewicz-MichalukJerzy Michaluk
Mar 1, 2005·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Zhe QuanYi-Ming Liu
Feb 16, 2016·Brain Research Bulletin·Momoko AbeKyoji Taguchi
Aug 26, 2015·Neurotoxicity Research·Agnieszka WąsikLucyna Antkiewicz-Michaluk
Nov 24, 2004·Neuropharmacology·Shou Yu YinMyung Koo Lee
Sep 13, 2005·Neuropharmacology·Jarogniew J LuszczkiStanislaw J Czuczwar
Feb 2, 2010·Brain Research·Nobuyuki KatagiriKyoji Taguchi
Aug 29, 2016·Neurotoxicity Research·Agnieszka WąsikLucyna Antkiewicz-Michaluk
May 4, 2004·Brain Research·Elzbieta Lorenc-KociJoanna Wierońska
Feb 8, 2005·Brain Research·Yaichiro KotakeShigeru Ohta
Jan 5, 2010·International Journal of Quantum Chemistry·Ming-Ju HuangYi-Ming Liu
Oct 23, 2012·Pharmacological Reports : PR·Agnieszka WąsikLucyna Antkiewicz-Michaluk
Jun 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Erwan Bezard, Serge Przedborski
Jun 18, 2017·Pharmacological Reports : PR·Agnieszka Wąsik, Lucyna Antkiewicz-Michaluk
Jan 9, 2014·Pharmacological Reports : PR·Kanako SaitohKyoji Taguchi