Stereoselective Effects of Abused "Bath Salt" Constituent 3,4-Methylenedioxypyrovalerone in Mice: Drug Discrimination, Locomotor Activity, and Thermoregulation

The Journal of Pharmacology and Experimental Therapeutics
Brenda M GannonWilliam E Fantegrossi

Abstract

3,4-Methylenedioxypyrovalerone (MDPV) is a common constituent of illicit "bath salts" products. MDPV is a chiral molecule, but the contribution of each enantiomer to in vivo effects in mice has not been determined. To address this, mice were trained to discriminate 10 mg/kg cocaine from saline, and substitutions with racemic MDPV, S(+)-MDPV, and R(-)-MDPV were performed. Other mice were implanted with telemetry probes to monitor core temperature and locomotor responses elicited by racemic MDPV, S(+)-MDPV, and R(-)-MDPV under a warm (28°C) or cool (20°C) ambient temperature. Mice reliably discriminated the cocaine training dose from saline, and each form of MDPV fully substituted for cocaine, although marked potency differences were observed such that S(+)-MDPV was most potent, racemic MDPV was less potent than the S(+) enantiomer, and R(-)-MDPV was least potent. At both ambient temperatures, locomotor stimulant effects were observed after doses of S(+)-MDPV and racemic MDPV, but R(-)-MDPV did not elicit locomotor stimulant effects at any tested dose. Interestingly, significant increases in maximum core body temperature were only observed after administration of racemic MDPV in the warm ambient environment; neither MDPV enantiom...Continue Reading

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Citations

Nov 14, 2018·The Journal of Pharmacology and Experimental Therapeutics·Catheryn D WilsonWilliam E Fantegrossi
Dec 9, 2017·The Journal of Pharmacology and Experimental Therapeutics·Brenda M GannonGregory T Collins
Feb 12, 2020·British Journal of Clinical Pharmacology·Raquel Santos-ToscanoColin Davidson
Feb 27, 2020·Behavioural Pharmacology·William S HyattWilliam E Fantegrossi
Jan 1, 2016·Journal of Drug and Alcohol Research·Brenda M Gannon, William E Fantegrossi
Mar 16, 2018·Drug Metabolism Reviews·Leandro Nóbrega, Ricardo Jorge Dinis-Oliveira
Oct 5, 2017·Journal of Analytical Toxicology·Bárbara SilvaFernando Remião
Mar 14, 2017·Analytical Methods : Advancing Methods and Applications·Michael D HambuchenS Michael Owens
Aug 17, 2021·Behavioural Pharmacology·Angela M ThomasLisa E Baker
Aug 21, 2021·The Journal of Pharmacology and Experimental Therapeutics·Michelle R DoyleGregory T Collins

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