PMID: 11918522Mar 29, 2002Paper

Stereoselective pharmacokinetics and pharmacodynamics of anti-asthma agents

The Annals of Pharmacotherapy
Majid VakilyDion Brocks

Abstract

To review the previously published studies on pharmacokinetics and pharmacodynamics of chiral drugs used in the treatment of asthma. Primary and review articles were identified with a MEDLINE search (1980-May 2001) and through secondary sources. All English-language studies and reviews obtained from the MEDLINE search pertaining to stereoselective pharmacokinetics and pharmacodynamics of chiral anti-asthma drugs were assessed. Several anti-asthma drugs (e.g., beta(2)-adrenergic agonists, leukotriene modifiers) are chiral and marketed as racemates, which consist of equal proportions of 2 enantiomers. Significant stereoselectivity has also been reported in pharmacodynamics and pharmacokinetics of the beta(2)-agonists. The enantiomers of beta(2)-agonists in the R configuration are primarily responsible for the bronchodilating effects of the racemate. The plasma concentrations of the enantiomers of anti-asthma drugs may differ as a reflection of stereoselectivity in clearance, volume of distribution, and route of administration. Stereoselectivity in the pharmacokinetics of anti-asthma drugs may complicate the relationship between dose and/or plasma concentration of racemic drug versus effect relationship. An appreciation of the ste...Continue Reading

References

Oct 1, 1976·Biochemical Pharmacology·C DaltonL B Czyzewski
Feb 20, 1992·The New England Journal of Medicine·W O SpitzerA S Rebuck
Jun 1, 1992·Chest·L C Grammer
Jun 1, 1992·Chest·C R Zeiss
Apr 1, 1990·Clinical Pharmacokinetics·D J Morgan
Jan 1, 1990·European Journal of Clinical Pharmacology·L BorgströmB Angelin
Sep 1, 1989·Journal of Pharmaceutical Sciences·F JamaliF M Pasutto
Jan 1, 1989·British Journal of Clinical Pharmacology·L BorgströmJ Paulson
May 1, 1973·British Journal of Pharmacology·R T BrittainR J Marshall
Sep 1, 1971·Journal of Medicinal Chemistry·D Hartley, D Middlemiss
Jul 1, 1973·Journal of Medicinal Chemistry·C J Hawkins, G T Klease
Apr 1, 1984·Clinical Pharmacology and Therapeutics·A RyrfeldtR Pauwels
Oct 1, 1994·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M R Sears, D R Taylor
Jan 1, 1993·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·P ArvidssonC G Löfdahl
Apr 1, 1993·Journal of Clinical Pharmacy and Therapeutics·N KurosawaS Kurosawa
Sep 1, 1995·Pharmacotherapy·D R Brocks, F Jamali
Oct 24, 1995·European Journal of Pharmacology·S LindbergT Runer
Oct 6, 1995·Journal of Chromatography. B, Biomedical Applications·D W Boulton, J P Fawcett
Jan 1, 1995·Clinical Pharmacokinetics·J M MachinistB A Bopp
Jan 1, 1996·British Journal of Clinical Pharmacology·D W Boulton, J P Fawcett
Jan 1, 1996·Clinical Reviews in Allergy & Immunology·R B PennJ L Benovic
Jan 1, 1996·Clinical Reviews in Allergy & Immunology·D W Boulton, J P Fawcett
Jan 1, 1996·Clinical Reviews in Allergy & Immunology·M Perrin-FayolleM T Chambe
Mar 1, 1996·British Journal of Clinical Pharmacology·E A EatonT Walle
Jan 1, 1996·Drugs·A J Hutt, S C Tan
Aug 1, 1997·Clinical Pharmacokinetics·R Mehvar, F Jamali
Dec 31, 1997·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A A WilsonT Walle
Feb 12, 1998·British Journal of Clinical Pharmacology·D W BoultonT M Fiddes
Mar 4, 1998·Hospital Practice·J M Drazen
Mar 21, 1998·Chirality·D A HandleyJ Morley
Dec 16, 1998·The Journal of Allergy and Clinical Immunology·H S NelsonP D Rubin
May 18, 1999·The Journal of Allergy and Clinical Immunology·B Waldeck
Aug 19, 1999·The Journal of Allergy and Clinical Immunology·D Handley
Sep 9, 1999·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·L García-Marcos, A Schuster

❮ Previous
Next ❯

Citations

May 6, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Silas W Smith
Apr 13, 2007·Expert Opinion on Drug Metabolism & Toxicology·Hong Lu
Aug 28, 2009·The Veterinary Journal·Aneliya Milanova Haritova, Johanna Fink-Gremmels
Feb 9, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Mihai-Sergiu Jalba
Sep 1, 2006·Biopharmaceutics & Drug Disposition·Dion R Brocks
Sep 21, 2010·Chemical Society Reviews·Barbara Kasprzyk-Hordern
Apr 15, 2004·Clinical Pharmacokinetics·Peter MansfieldAnne Tonkin
Jan 26, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Silas W SmithJeffrey K Aronson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.