Stereoselective synthesis of an active metabolite of the potent PI3 kinase inhibitor PKI-179

The Journal of Organic Chemistry
Zecheng ChenTarek S Mansour

Abstract

The synthesis and stereochemical determination of 1-(4-(4-((1R,5R,6R)-6-hydroxy-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea (2), an active metabolite of the potent PI3 kinase inhibitor PKI-179 (1), is described. Stereospecific hydroboration of the double bond of 2,5-dihydro-1H-pyrrole 8 gave the 2,3-trans alcohol 9 exclusively. The configuration of the 3-hydroxyl group in 9 was inverted by an oxidation and stereoselective reduction sequence to give the corresponding 2,3-cis isomer 23. Both exo (21) and endo (27) isomers of the metabolite 2 were prepared via a practical synthetic route from 9 and 23, respectively, and the stereochemistry of 2 was determined to be endo. The endo isomer (27) was separated into two enantiomers 28 and 29 by chiral HPLC. Compound 2 was found to be enantiomerically pure and identical to the enantiomer 28. The absolute stereochemistry of the enantiomer 28 was determined by Mosher's method, thus establishing the stereochemistry of the active metabolite 2.

References

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Citations

Jun 27, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Tomasz M WróbelDariusz Matosiuk
Oct 19, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Abdul MutlibJoann Scatina
Nov 28, 2019·International Journal of Molecular Sciences·Kimiko L KriegerNicholas T Woods
Aug 22, 2013·Chemical Communications : Chem Comm·Rachael BogackiLaura C Paterson
Aug 28, 2010·Bioorganic & Medicinal Chemistry Letters·Aranapakam M VenkatesanTarek S Mansour

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