Stereoselective synthesis of axially chiral N-C bonds in N-aryl indoles

Organic Letters
Ken KamikawaMotokazu Uemura

Abstract

[reaction: see text] N-Aryl indoles with axially chiral N-C bonds were synthesized by stereoselective nucleophilic aromatic substitution reactions of planar chiral arene chromium complexes. Stereoselective chromium tricarbonyl migration was achieved in the sterically hindered N-aryl indole chromium complex by refluxing in toluene.

Citations

Aug 28, 2007·Chemical Society Reviews·Marta RosilloJavier Pérez-Castells
Nov 11, 2016·Organic & Biomolecular Chemistry·A CiogliC Villani
May 13, 2010·Chemistry : a European Journal·Nobutaka OtotakeOsamu Kitagawa
May 22, 2018·Chemical Science·Jagadeesh KalepuLukasz T Pilarski
May 5, 2020·Chemistry : a European Journal·Tian-Zhen LiFeng Shi
Oct 20, 2020·Chemistry : a European Journal·Vinzenz Thönnißen, Frederic W Patureau

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