Stereoselective Synthesis of Cyclohexanes via an Iridium Catalyzed (5 + 1) Annulation Strategy

Journal of the American Chemical Society
Wasim M AkhtarTimothy J Donohoe

Abstract

An iridium catalyzed method for the synthesis of functionalized cyclohexanes from methyl ketones and 1,5-diols is described. This process operates by two sequential hydrogen borrowing reactions, providing direct access to multisubstituted cyclic products with high levels of stereocontrol. This methodology represents a novel (5 + 1) strategy for the stereoselective construction of the cyclohexane core.

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Citations

Mar 23, 2019·Organic & Biomolecular Chemistry·Meng-Juan ZhangJian-Ping Lang
Jul 6, 2019·Chemical Communications : Chem Comm·Tatsuya MorofujiNaokazu Kano
Jul 3, 2019·Angewandte Chemie·Roly J ArmstrongTimothy J Donohoe
Feb 28, 2020·Chemical Communications : Chem Comm·Daniella M J CheangTimothy J Donohoe
Feb 28, 2020·Chemical Communications : Chem Comm·Anna E R ChamberlainTimothy J Donohoe
Apr 17, 2020·Chemistry : a European Journal·Timothy KwokTimothy James Donohoe
Oct 1, 2020·Chemical Communications : Chem Comm·Léo BettoniJean-Luc Renaud
Jun 27, 2019·ChemSusChem·Priyanka ChakrabortyBasker Sundararaju
Apr 22, 2020·Angewandte Chemie·Simon WübboltTimothy J Donohoe
Dec 5, 2020·Angewandte Chemie·Liyin JiangMarcos G Suero
Jun 1, 2021·ACS Central Science·Benjamin G Reed-BerendtLouis C Morrill
Oct 30, 2019·Journal of the American Chemical Society·Akash KaithalWalter Leitner
Jan 23, 2020·Journal of the American Chemical Society·Lewis B SmithTimothy J Donohoe
Jun 20, 2020·Organic Letters·Anju NalikezhathuTravis J Williams
Sep 7, 2021·Chemical Communications : Chem Comm·Sourajit BeraDebasis Banerjee

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