PMID: 2497485Jan 1, 1989Paper

Stereospecific actions of baclofen on sociosexual behavior, locomotor activity and motor execution

Psychopharmacology
R G Paredes, A Agmo

Abstract

The behavior effects of racemic baclofen and the R and S enantiomers were studied in order to determine whether the stereospecificity found in receptor binding studies also applies to the behavioral actions of the drug. Racemic and R-baclofen inhibited sexual behavior, locomotor activity and motor execution at relatively low doses while s-baclofen was completely inactive even when a dose 40 times higher than the minimum effective dose of R-baclofen was used. The R enantiomer seems to be twice as active as racemic baclofen. These data strongly suggest that the behavioral effects of baclofen are the result of an action at the GABA-B receptor. In order to differentiate the effects of baclofen on sexual interactions from those on nonspecific social interactions, the sociosexual behavior was observed with a castrated male or a receptive female as stimulus animal. R, S-baclofen had effects only upon sociosexual interaction with a receptive female. Moreover, the inhibitory effects of baclofen were restricted to behavioral items related to sexual interactions, primarily those constituting precopulatory behaviors. Since no effect was observed in social interactions with a castrated male, it is suggested that the inhibition of sociosexua...Continue Reading

References

Nov 1, 1978·European Journal of Pharmacology·H R OlpeH L Haas
Mar 22, 1985·Neuroscience Letters·H L HaasH R Olpe
Jan 1, 1989·Journal of Neural Transmission·A Agmo, H Fernández
Jun 19, 1985·European Journal of Pharmacology·A Agmo, R Paredes
Feb 23, 1987·Life Sciences·M N RittaR S Calandra
Nov 23, 1984·Neuroscience Letters·A J CrossD Markakis
Jan 1, 1983·British Journal of Pharmacology·N G BoweryA L Hudson
Jan 1, 1984·Neurochemistry International·F V Defeudis
Jan 1, 1984·Neurochemistry International·Y Yondea, K Kuriyama

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Citations

Jan 1, 1989·Journal of Neural Transmission·A Agmo, H Fernández
Jan 1, 1996·Journal of Neural Transmission·A AgmoM Giordano
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·A Agmo, Z Picker
Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·A Agmo, H Fernández
Nov 12, 1998·Physiology & Behavior·M GiordanoR G Paredes
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·K BrebnerD C Roberts
Sep 1, 1997·Pharmacology, Biochemistry, and Behavior·A AgmoP Alonso
Sep 23, 1997·Pharmacology, Biochemistry, and Behavior·R G ParedesA Agmo
May 1, 1997·Brain Research. Brain Research Protocols·A Agmo
Aug 1, 2013·Neurotoxicology and Teratology·R FerriM M Bernardi
Aug 31, 2010·Research in Veterinary Science·M M BernardiH Manzano
Mar 3, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Liana FattorePaola Fadda
Jun 15, 2007·Research in Veterinary Science·Patricia S B Rodrigues-AlvesHelenice de S Spinosa
Aug 14, 2003·Scandinavian Journal of Psychology·Raúl G Paredes
Jun 29, 2004·Pharmacology, Biochemistry, and Behavior·M L Andersen, S Tufik
Mar 19, 2013·Pharmacology, Biochemistry, and Behavior·T J R BeveridgeL J Porrino
Mar 11, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J L SilvermanJ N Crawley
May 6, 2016·Frontiers in Psychiatry·Irene LorraiGiancarlo Colombo
Jun 14, 2016·Journal of Neurogenetics·Eric J HorstickHarold A Burgess
Aug 7, 1998·Journal of Psychopharmacology·R G ParedesA Agmo
Jun 18, 2019·Chemical Biology & Drug Design·Zuleyma Martínez-CamposRodrigo Said Razo-Hernández
Jul 27, 2000·Annals of the New York Academy of Sciences·D C Roberts, K Brebner

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