Stereospecific inhibition of PGH2-induced platelet aggregation by lipoxygenase products of icosaenoic acids

Biochemical and Biophysical Research Communications
M Croset, M Lagarde

Abstract

Mono-hydroxylated fatty acids were prepared from the three prostaglandin precursors (20:3, 20:4 and 20:5) through the platelet 12-lipoxygenase or the soybean 15-lipoxygenase and were purified by HPLC. The inhibition of PGH2-induced human platelet aggregation by these hydroxy derivatives was compared. Other hydroxy derivatives of arachidonic acid of physiological importance were also tested in that respect. We have found that 12- or 15- hydroxy-icosaenoic acids are the most potent inhibitors. As compared to 12- or 15-hydroxy -20:4 (12- or 15-HETE), 5-HETE was about three fold less potent. We have also found that leukotriene B4 (5S, 12R-diHETE) is completely devoid of inhibitory activity while its isomer 5S, 12S-diHETE shares the activity of every mono-hydroxy-icosaenoic acids which are also S derivatives. We conclude that hydroxy derivatives of icosaenoic acids can inhibit PGH2-induced platelet aggregation by structural analogy and that they need a S configuration. These findings point out a possible negative feed back modulation of platelet aggregation by the lipoxygenase products of arachidonic acid and other icosaenoic acids which can arise in platelets subsequently to dietary manipulations.

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S Hammarström, P Falardeau
Feb 20, 1975·Biochimica Et Biophysica Acta·D H Nugteren
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Nov 12, 1982·Biochimica Et Biophysica Acta·D Boukhchache, M Lagarde
Nov 16, 1982·Biochemical and Biophysical Research Communications·A J MarcusG Weissmann
Feb 1, 1981·Journal of Medicinal Chemistry·P Borgeat, P Sirois
Apr 30, 1981·Biochemical and Biophysical Research Communications·M LagardeM Dechavanne
Jan 1, 1981·Progress in Lipid Research·E Vericel, M Lagarde
Feb 1, 1980·Thrombosis Research·M LagardeM Dechavanne

❮ Previous
Next ❯

Citations

Mar 1, 1993·American Journal of Hematology·K Jaschonek, C Faul
Dec 1, 1994·Cancer Metastasis Reviews·K V HonnW Hagmann
Feb 1, 1996·Inflammation·M KöllerW König
Sep 1, 1985·Basic Research in Cardiology·K Schrör
Jul 22, 1988·Biochimica Et Biophysica Acta·M CrosetM Lagarde
Feb 25, 1992·European Journal of Pharmacology·M TawataT Onaya
Jan 14, 1994·European Journal of Pharmacology·J M FayardC Laugier
Sep 1, 1990·Prostaglandins·G HonstraW Uedelhoven
Jan 1, 1986·Progress in Lipid Research·A Nordøy
Jan 1, 1984·Prostaglandins, Leukotrienes, and Medicine·M LagardeS Renaud
Feb 1, 1986·Prostaglandins, Leukotrienes, and Medicine·M R BuchananD J Nazir
Dec 23, 2015·Toxicon : Official Journal of the International Society on Toxinology·Celia R Carlini, Rodrigo Ligabue-Braun
Sep 22, 2015·Biomedical Chromatography : BMC·Xiaolei RenXueyong Wang
Mar 9, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M LagardeM Guichardant
Oct 1, 1984·European Journal of Clinical Investigation·A NordøyS Renaud
Apr 2, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Benedetta PorroViviana Cavalca
Jan 6, 2018·Journal of Lipid Research·Liudmila L MazaleuskayaClementina Mesaros
Sep 14, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ping ChenMichel Guichardant
Aug 15, 1985·International Journal of Cancer. Journal International Du Cancer·R A KnazekJ Costa
Mar 25, 2019·Biochemical Society Transactions·Monica Napolitano
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·A Nordøy
Nov 16, 2020·The Journal of Allergy and Clinical Immunology·William C ScottJustin H Turner
Oct 1, 1991·The American Journal of Physiology·E E GordonA A Spector

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.