Stereotactic ablative body radiotherapy for lung cancer

Clinical Oncology : a Journal of the Royal College of Radiologists
K N FranksM P Snee

Abstract

Lung stereotactic ablative radiotherapy (SABR) is a method of delivering high 'ablative' doses of radiotherapy to tumours in the lung. It was developed at the Karolinska Institute in the early 1990s using the methods established in cranial radiosurgery with multiple beams prescribed to an isodose and using a custom designed stereotactic body frame for immobilisation. Since then, aligned with the advances in radiotherapy technology and techniques (e.g. four-dimensional computed tomography simulation and image-guided radiotherapy), there has been a rapid increase in the use of lung SABR for both early stage lung cancer and lung metastases. For peripheral primary lung cancers less than 5 cm in diameter, high rates of local control and low levels of acute and late toxicity are consistently reported in the published literature. Compared with historical control rates of stage I lung cancers treated with conventionally fractionated radiotherapy, SABR seems to offer higher rates of local control, lower levels of acute toxicity and a better quality of life after treatment. However, the full results of randomised controlled trials of SABR versus conventionally fractionated are awaited and will provide higher-level evidence. For central l...Continue Reading

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Citations

Oct 1, 2016·Clinical Oncology : a Journal of the Royal College of Radiologists·R Jena
Sep 11, 2018·Journal of Applied Clinical Medical Physics·Grace E A HealyAndrew T Cousins
Aug 25, 2020·Interactive Cardiovascular and Thoracic Surgery·Cecilia PompiliGalina Velikova
Feb 13, 2021·Physics in Medicine and Biology·Vadim Y Kuperman, Leslie M Lubich

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