Stereotactic Ablative Body Radiotherapy Versus Radical Radiotherapy: Comparing Real-World Outcomes in Stage I Lung Cancer

Clinical Oncology : a Journal of the Royal College of Radiologists
I PhillipsS Harden

Abstract

Stereotactic ablative body radiotherapy (SABR) is now considered the standard of care for medically inoperable stage I non-small cell lung cancer (NSCLC). The English National Cancer Registration and Analysis Service (NCRAS) collects data on all patients diagnosed with lung cancer, including information on treatment. We wanted to compare outcomes for patients with stage I NSCLC treated with radical radiotherapy with either SABR or fractionated radiotherapy. All patients diagnosed with stage I NSCLC in 2015 and 2016 were identified from the NCRAS dataset, validated by the National Lung Cancer Audit, and their treatment data were collated. For patients who received radiotherapy, those receiving radical dose fractionations, including SABR, were identified through linkage to the national Radiotherapy Dataset. Clinical outcomes for those receiving SABR or more fractionated radical radiotherapy were compared using univariate and fully adjusted Cox proportional hazards models. In total, 12 384 patients with stage I NSCLC were identified during the study period; 53.5% underwent surgical resection, 24.3% received no documented treatment, 18.6% received radical radiotherapy and 3.5% received other non-curative-intent treatments. For thos...Continue Reading

Citations

Feb 12, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·C PowellT Roques
May 7, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Tobias FinazziSuresh Senan
May 19, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·S BrownM van Herk
Feb 9, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·S MerciecaM van Herk

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