Stereotactic body radiation therapy in patients with pelvic recurrence from rectal carcinoma

Japanese Journal of Clinical Oncology
Mi-Sook KimHyeJeong Kang

Abstract

To investigate the clinical applications of stereotactic body radiation therapy (SBRT) using the CyberKnife system for pelvic recurrence from rectal cancer with a focus on survival and toxicity. Between 2002 and 2006, 23 patients with recurrent rectal cancer were treated with SBRT at our institution. The median follow-up was 31 months. Sites of recurrence were pre-sacral in seven patients and the pelvic wall in 16. SBRT doses ranged from 30 to 51 Gy (median 39 Gy) and were delivered in three fractions. Response to treatment was assessed by computed tomography. Overall and local progression-free survival and toxicities were recorded. Four-year overall survival and local control rates were 24.9 and 74.3%, respectively. No prognostic factor was found to affect patient survival or local progression. One patient developed a severe radiation-related toxicity, but recovered completely after treatment. SBRT for pelvic recurrence was found to be comparable with other modalities with respect to overall survival and complication rates. Further studies are needed to confirm these preliminary results.

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Citations

Apr 8, 2010·Clinical & Experimental Metastasis·Jin-Kyu KangUi-Sup Shin
Jun 28, 2011·Radiation Oncology·Sylvain DewasEric Lartigau
Dec 23, 2009·World Journal of Gastroenterology : WJG·Mi-Sook KimYoung Joo Shin
May 19, 2010·Gut and Liver·Jin-Seok ParkSo-Yun Nha
Apr 26, 2014·World Journal of Gastroenterology : WJG·Atsuya TakedaEtsuo Kunieda
May 28, 2014·Current Oncology Reports·Gregory M M Videtic
Dec 24, 2015·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Barbara Alicja Jereczek-FossaRoberto Orecchia
Jan 2, 2013·The Lancet Oncology·Alison C TreeNicholas J van As
Apr 11, 2012·CA: a Cancer Journal for Clinicians·Lauren KosinskiRodrigo Perez
Jan 24, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marianne Grønlie GurenKjell Magne Tveit
Nov 12, 2014·Techniques in Coloproctology·F SelvaggiS Pucciarelli
Sep 28, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ralph R Weichselbaum
May 4, 2018·Japanese Journal of Clinical Oncology·Eun Kyung PaikHyung Jun Yoo
Apr 20, 2019·Frontiers in Oncology·Shing Yau Tam, Vincent W C Wu
Sep 14, 2019·Clinical and Translational Radiation Oncology·Shalini MoningiEmma B Holliday
May 4, 2021·Journal of the Anus, Rectum and Colon·Shigeru YamadaHiroshi Tsuji
Jul 10, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·R KinjP Y Bondiau
Oct 20, 2021·Annals of Surgical Oncology·Shigeru YamadaUNKNOWN Working Group on Locally Recurrent Rectal Cancer

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