Stereotactic body radiation therapy versus no treatment for early stage non-small cell lung cancer in medically inoperable elderly patients: A National Cancer Data Base analysis

Cancer
Ronica H NandaKristin A Higgins

Abstract

Stereotactic body radiation therapy (SBRT) has demonstrated high rates of local control with low morbidity and has now emerged as the standard of care for medically inoperable, early stage non-small cell lung cancer (NSCLC). However, the impact of lung SBRT on survival in the elderly population is less clear given competing comorbid conditions. An analysis of the National Cancer Data Base (NCDB) was undertaken to determine whether definitive SBRT improves survival relative to observation alone patients ages 70 years and older. The NCDB, a retrospective national database that captures approximately 70% of all patients treated for cancer, was queried for patients aged 70 years or older with early stage (T1-T3N0M0) NSCLC from 2003 to 2006. Overall survival was compared between patients who received stereotactic body radiotherapy alone and those who received no treatment. An extended Cox proportional hazards model was applied to estimate the treatment effect of SBRT. In total, 3147 patients met the selection criteria for this analysis. SBRT was delivered to 258 patients (8.2%), and 2889 patients (91.8%) received no treatment. There was no significant difference in the distribution of Charlson/Deyo comorbidity index scores between t...Continue Reading

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Citations

Jan 23, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Elizabeth A DavidRobert J Canter
Mar 24, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alba FiorentinoFilippo Alongi
Apr 4, 2017·International Journal of Radiation Oncology, Biology, Physics·Penny FangGrace L Smith
Dec 23, 2016·Expert Review of Respiratory Medicine·Marjolein A HeuvelmansMatthijs Oudkerk
Apr 14, 2018·The British Journal of Radiology·Tatsuhiko SaitoKoichi Tokuuye
Jul 22, 2017·The Cancer Journal·Myer Raphael Pfeffer, Philip Blumenfeld
Oct 4, 2017·Journal of Oncology Practice·Jeffrey A Bogart, Jason Wallen
Jan 3, 2021·Current Oncology Reports·Ammoren DohmRonica H Nanda
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Dec 18, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Animesh SahaJohn Lilley
May 7, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Tobias FinazziSuresh Senan
Apr 27, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Neal AndruskaUNKNOWN Advanced Radiation Therapy Committee for the International Association for the Study of Lung Cancer

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