Stereotactic body radiation therapy versus conventionally fractionated radiation therapy for early stage non-small cell lung cancer

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Waqar HaqueBin S Teh

Abstract

To date, no published randomized trials have shown stereotactic body radiation therapy (SBRT) to offer superior outcomes to conventionally fractionated radiation therapy (CFRT) for early-stage non-small cell lung cancer (NSCLC). The largest study to date, this investigation of a contemporary national database sought to evaluate practice patterns and survival between CFRT and SBRT. The National Cancer Database was queried (2004-2015) for histologically-confirmed cT1-2aN0M0 NSCLC undergoing definitive CFRT or SBRT. Multivariable logistic regression ascertained factors associated with SBRT administration. Kaplan-Meier analysis evaluated overall survival (OS) before and following propensity matching. Cox proportional hazards modeling determined variables associated with OS. Of 23,088 patients, 2286 (10%) patients received CFRT and 20,802 (90%) SBRT. SBRT was less often delivered in African-Americans, patients with lower incomes, urban location, greater comorbidities, at non-academic centers, in larger tumors, and squamous histology (p < 0.05 for all). Patients treated with SBRT had a higher median OS (38.8 months vs. 28.1 months, p < 0.001). At median follow-up of 44.6 months, the median OS for the SBRT group was 38.8 months, versu...Continue Reading

Citations

Apr 5, 2019·Dose-response : a Publication of International Hormesis Society·Li Yan DaiXiu Mei Ma
Jun 7, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Brendon M StilesArt Sedrakyan
Jun 26, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Marta AdamczykTomasz Piotrowski
Feb 22, 2021·Seminars in Radiation Oncology·Anna Wrona, Francoise Mornex
Jul 6, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·William R KennedyClifford G Robinson
Jun 7, 2021·Clinical Radiology·C D StrangeJ J Erasmus
Dec 11, 2021·Acta Oncologica·Lukas LöflingGunnar Wagenius

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.