Stereotactic body radiotherapy for early stage lung cancer: History and updated role

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Umberto RicardiAndrea Riccardo Filippi

Abstract

Stereotactic Body Radiotherapy (SBRT) represents a consolidated treatment option for patients with medically inoperable early stage non-small cell lung cancer (NSCLC). The clinical evidence accumulated over the past decade supports its use as an alternative to surgery with comparable survival outcomes. Due to its limited toxicity, SBRT is also applicable to elderly patients with very poor baseline pulmonary function or other severe comorbidities. Recent comparative studies in operable patients raised the issue of the possible use of SBRT also for this subgroup, with quite promising results that still should be fully confirmed by prospective trials with long-term follow up. In early stage lung cancer, clinicians are now faced with a decision-making process that should take into account different factors. The need of pathological diagnosis and accurate nodal staging still represents a challenge, as well as the interpretation of radiological findings after SBRT, often confusing du to the difficulties in distinguishing between radiation-induced changes and local relapse. Aim of this review is to summarize and discuss the major studies on SBRT for early stage lung cancer, providing data on its efficacy and toxicity and discussing th...Continue Reading

References

Jan 9, 1998·International Journal of Radiation Oncology, Biology, Physics·G S SibleyL R Prosnitz
Oct 31, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J WulfM Flentje
May 30, 2002·AJR. American Journal of Roentgenology·Titus R KoenigCraig W Stevens
Aug 24, 2005·International Journal of Radiation Oncology, Biology, Physics·Ronald C McGarryRobert D Timmerman
Oct 8, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Joern WulfMichael P Flentje
Oct 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert TimmermanJames Fletcher
Mar 14, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·David J HoopesRonald C McGarry
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hisao Asamura
Jan 27, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Si Yeol SongEun Kyung Choi
Mar 31, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael T MilanoPaul Okunieff
May 6, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pia BaumannRolf Lewensohn
Jun 27, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Umberto RicardiRiccardo Ragona
Jan 13, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Inga S GrillsLarry L Kestin
Jan 16, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Alexander ChiRitsuko Komaki
Mar 18, 2010·JAMA : the Journal of the American Medical Association·Robert TimmermanHak Choy
Apr 7, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C Clifton LingEllen Yorke
Apr 20, 2010·The Journal of Thoracic and Cardiovascular Surgery·Traves D CrabtreeJeffrey D Bradley
Jul 20, 2010·International Journal of Radiation Oncology, Biology, Physics·Hiroshi OnishiTsutomu Araki
Aug 17, 2010·International Journal of Radiation Oncology, Biology, Physics·Samuel BralGuy Storme
Oct 1, 2010·Medical Physics·Stanley H BenedictFang-Fang Yin
Nov 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David PalmaSuresh Senan
Jul 5, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicolaus AndratschkeHans Geinitz
Sep 6, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Atsuya TakedaYukihiko Ozawa
Sep 6, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Cornelis J A HaasbeekSuresh Senan
Nov 23, 2011·International Journal of Radiation Oncology, Biology, Physics·Frank J LagerwaardSuresh Senan
Jan 20, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Matthias GuckenbergerInga S Grills
Jan 24, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Joost J NuyttensMischa S Hoogeman
May 23, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Frank J LagerwaardSuresh Senan
Jun 15, 2012·The New England Journal of Medicine·Michael N CorradettiRamesh Rengan
Jul 31, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Inga Siiner GrillsJose Belderbos
Jul 31, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Bryan P RoweRoy H Decker
Sep 15, 2012·International Journal of Radiation Oncology, Biology, Physics·Shervin M ShirvaniBenjamin D Smith
Mar 7, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sashendra SenthiSuresh Senan
May 28, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicolas PeguretWilko F A R Verbakel
Jun 4, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pierina NavarriaMarta Scorsetti
Aug 21, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kitty HuangSuresh Senan
Sep 11, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ursula NestleCecile le Pechoux
Nov 5, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eva M BongersSuresh Senan
Dec 19, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Dirk De Ruysscher

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Citations

May 2, 2017·American Journal of Respiratory and Critical Care Medicine·Anil VachaniAvrum Spira
Dec 23, 2016·The British Journal of Radiology·Neil B DesaiRobert D Timmerman
Sep 5, 2018·Journal of Bronchology & Interventional Pulmonology·Adam R BelangerJason A Akulian
Oct 17, 2018·The British Journal of Radiology·Francesco DeodatoAlessio G Morganti
Jul 10, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Daniel P Steinfort, Felix J F Herth
Jun 8, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y SunR Wu
Aug 24, 2017·Journal of Thoracic Imaging·Marcelo F BenvenisteEdith M Marom
Dec 6, 2017·Cardiovascular and Interventional Radiology·Yuntong MaJack W Jennings
Jan 9, 2018·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Walter WederGaetano Rocco
Nov 25, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Yamei ChenXiao Hu
Aug 3, 2020·The Annals of Thoracic Surgery·Marnix J A RasingPeter S N van Rossum

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