Stereotactic Body Radiotherapy for Small Unresectable Hepatocellular Carcinomas

Clinical Oncology : a Journal of the Royal College of Radiologists
Rosanna YeungDevin Schellenberg

Abstract

Stereotactic body radiotherapy (SBRT) is an option for the treatment of hepatocellular carcinoma (HCC) in patients ineligible for standard local therapies. This study reports on the safety and efficacy of SBRT in small HCC tumours (≤5 cm) in the province of British Columbia. Between March 2011 and July 2015, 31 patients with Child-Pugh Class A or B, with small HCCs measuring ≤5 cm were treated with SBRT at our institution. Primary end points were local control, progression-free survival, overall survival and toxicity. Thirty-four hepatomas (median size 3.3 cm, range 1.3-5.0 cm) were treated. The median follow-up was 18.3 months. Twenty-six patients (84%) had received previous liver-directed treatments. Most patients (88%) were treated with 45 Gy in three or five fractions. Six patients (19%) had worsened Child-Pugh score by two or more points during follow-up; overall 32% of patients experienced ≥ grade 3 + toxicities. One-year local control and overall survival were 94 and 84%, respectively. One-year progression-free survival was 49%; 81% of patients with disease progression received further HCC therapy. On univariate analysis, small tumour size predicted for improved overall survival (P = 0.01) whereas prescription biological...Continue Reading

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Citations

Mar 17, 2020·Journal of Medical Imaging and Radiation Oncology·Kevin My LoHui Jun Xu
Aug 25, 2019·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·O RiouD Azria
Jun 25, 2021·Journal of Hepatocellular Carcinoma·Ashwathy S Mathew, Laura A Dawson
Jul 18, 2021·Current Problems in Cancer·Allison F O'NeillKhashayar Vakili
Feb 26, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·L BeatonR Ma
Nov 12, 2021·The British Journal of Radiology·Laura BeatonRicky A Sharma

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