Stereotactic body radiotherapy for the treatment of medically inoperable primary renal cell carcinoma: Current evidence and future directions

Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada
Anand Swaminath, William Chu

Abstract

The incidence of renal cell carcinoma (RCC) is steadily rising due to an aging population and more frequent imaging of the abdomen for other medical conditions. While surgery remains the standard of care treatment for localized disease, many patients are unfit due to their advanced age and medical comorbidities. In these patients, an active surveillance strategy or ablative therapies, including radiofrequency/microwave ablation or cryotherapy, can be offered. Such options have limitations particularly with fast growing, or larger tumors. A promising ablative therapy option to consider is stereo-tactic body radiotherapy (SBRT). SBRT refers to high dose, focally ablative radiation delivered in a short time (3-5 fractions), and is safe and effective in many other cancer sites, including lung, liver and spine. SBRT offers potential advantages in the primary kidney cancer setting due to its ablative dosing (overcoming the notion of "radio-resistance"), short treatment duration (important in an elderly population), low toxicity profile (enabling SBRT to treat larger RCCs than other ablative modalities), and non-invasiveness. To date, there is limited long-term prospective data on the outcomes of SBRT in primary RCC. However, early ev...Continue Reading

Citations

Jan 13, 2016·Current Urology Reports·Michael J BilesSolomon L Woldu
May 2, 2016·Clinical Oncology : a Journal of the Royal College of Radiologists·J H ChangW Chu
Mar 16, 2018·Journal of Applied Clinical Medical Physics·Atallah BaydounRodney Ellis
Jul 15, 2017·Cancer·Susanna W L de GeusJennifer F Tseng
Mar 28, 2019·AJR. American Journal of Roentgenology·Christopher S LimStuart G Silverman
Jun 21, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anurag K SinghJason B Muhitch
Mar 30, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·A SwaminathW Chu
Apr 19, 2021·Journal of Radiation Research·Takaya YamamotoKeiichi Jingu

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