Stereotactic body radiotherapy in the management of oligometastatic and recurrent biliary tract cancer: single-institution analysis of outcome and toxicity

Journal of Cancer Research and Clinical Oncology
Ciro FranzeseMarta Scorsetti

Abstract

Biliary tract cancers (BTC) are rare malignancies arising from biliary system. Systemic therapy is the cornerstone for stage IV disease, with poor overall survival (OS). Evidence is lacking about safety and efficacy of local ablative treatments, such as surgery and stereotactic body radiotherapy (SBRT) in the context of metastatic BTC (mBTC). We retrospectively analyzed clinical outcomes for a cohort of mBTC patients treated with SBRT for oligometastatic disease. Inclusion criteria were 1-5 distant metastases; SBRT with a dose/fraction of a least 5 Gy to a biological effective dose (BED) of at least 40 Gy considering an α/β of 10 Gy. Analyzed outcomes included local control (LC), distant progression-free survival (DPFS), PFS, and OS. 51 patients meeting the inclusion criteria. Primary tumor sites were intrahepatic cholangiocarcinoma (35%), extrahepatic cholangiocarcinoma (31%), ampullary adenocarcinoma (20%), gallbladder adenocarcinoma (14%). 21 patients were treated on liver lesions, 17 on nodal metastasis, 5 patients on lung lesions, 4 patients on recurrence along the extrahepatic bile duct. After a median follow-up of 14 months median OS was 13.7 months, 1- and 2-year OS were 58% and 41%, respectively. Node and lung as metas...Continue Reading

References

Sep 1, 1996·Archives of Surgery·K YamaguchiM Tanaka
Aug 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B GlimeliusC Svensson
Jan 1, 1956·American Journal of Surgery·C D SAWYER, J F MINNIS
Apr 25, 2007·World Journal of Surgery·Suguru HasegawaYasuyuki Shimahara
Apr 9, 2010·The New England Journal of Medicine·Juan ValleUNKNOWN ABC-02 Trial Investigators
Oct 18, 2014·Radiation Oncology Journal·Da Hoon JungSang Bum Kim
May 13, 2015·Best Practice & Research. Clinical Gastroenterology·Annika Bergquist, Erik von Seth
Apr 29, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ciro FranzeseMarta Scorsetti
Nov 11, 2016·Chinese Clinical Oncology·Vitor Werneck Krauss SilvaJinru Shia
Mar 21, 2017·Anticancer Research·Tetsuzo TagawaYoshihiko Maehara
Aug 19, 2017·Cancer Discovery·Juan W ValleAndrew X Zhu
Mar 8, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R J KlementM Guckenberger
Sep 13, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Jeongshim LeeChai Hong Rim
Jan 17, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Lotte WilkeMatthias Guckenberger

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