Stereotactic body radiotherapy (SBRT) with or without surgery for primary and metastatic liver tumors

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Alexander KirichenkoNgoc Thai

Abstract

We report single center experience on the outcome and toxicity of SBRT alone or in combination with surgery for inoperable primary and metastatic liver tumors between 2007 and 2014. Patients with 1-4 hepatic lesions and tumor diameter ≤9 cm received SBRT at 46.8Gy ± 3.7 in 4-6 fractions. The primary end point was local control with at least 6 months of radiographic followup, and secondary end points were toxicity and survival. Eighty-seven assessable patients (114 lesions) completed liver SBRT for hepatoma (39) or isolated metastases (48) with a median followup of 20.3 months (range 1.9-64.1). Fourteen patients underwent liver transplant with SBRT as a bridging treatment or for tumor downsizing. Eight patients completed hepatic resections in combination with planned SBRT for unresectable tumors. Two-year local control was 96% for hepatoma and 93.8% for metastases; it was 100% for lesions ≤4 cm. Two-year overall survival was 82.3% (hepatoma) and 64.3% (metastases). No incidence of grade >2 treatment toxicity was observed. In this retrospective analysis we demonstrate that liver SBRT alone or in combination with surgery is safe and effective for the treatment of isolated inoperable hepatic malignancies and provides excellent loca...Continue Reading

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Citations

Jan 24, 2018·World Journal of Gastrointestinal Surgery·Shaakir HasanAlexander V Kirichenko
Apr 30, 2017·Oncology Letters·Marcel MatzenauerBohuslav Melichar
Aug 13, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Naoto GotohdaTetsuo Akimoto
Oct 7, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Beat MoeckliGonzalo Sapisochin
Nov 7, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Shaakir HasanAlexander Kirichenko

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